Asymmetrical dimethyl arginine in type 2 diabetic patients with coronary artery disease

Objective: To compare clinical and biochemical parameters for type 2 diabetic patients having coronary artery disease with controls. Methods: The analytical, cross-sectional study was conducted at Khyber Medical College, Peshawar, Pakistan, for a period of one year between 2010 and 2011, and comprised two groups; Group A had normal controls, while Group B had type 2 diabetic patients with coronary artery disease. Clinical parameters were blood pressure and bodymass index. Blood was centrifuged for blood sugar, glycosylated haemoglobin, total cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride and asymmetrical dimethylarginine. SPSS 15 was used to analyse data. Results: Of the 150 subjects, there were 75(50%) each in Group A and Group B, which had the mean age of 50.8 +/- 80 years and 53.4 +/- 52 years, respectively. Both systolic and diastolic blood pressure and body mass index were raised and an elevated level of serum asymmetric dimethylarginine, fasting blood sugar, total cholesterol, triglycerides, glycosylated haemoglobin was noted among Group B patients (p < 0.05). Conclusion: All clinical and biochemical parameters were found raised among diabetic patients with coronary artery disease.