Integrin signaling: Cytoskeletal complexes, MAP kinase activation, and regulation of gene expression

被引：49

作者：

Danen, EHJ ^{[1
]}

Lafrenie, RM ^{[1
]}

Miyamoto, S ^{[1
]}

Yamada, KM ^{[1
]}

机构：

[1] NIDR, CDBRB, NIH, Bethesda, MD 20892 USA

来源：

CELL ADHESION AND COMMUNICATION | 1998年 / 6卷 / 2-3期

关键词：

cell adhesion; extracellular matrix; fibronectin; integrin; signal transduction;

D O I：

10.3109/15419069809004477

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the integrin family of adhesion receptors mediate interactions of cells with the extracellular matrix. Besides their role in tissue morphogenesis by anchorage of cells to basement membranes and migration along extracellular matrix proteins, integrins are thought to play a key role in mediating the control of gene expression by the extracellular matrix. Studies over the past 10 years have shown that integrin-mediated cell adhesion can trigger signal transduction cascades involving translocation of proteins and protein tyrosine phosphorylation events. In this review, we discuss approaches used in our lab to study early events in integrin signalling as well as further downstream changes.

引用

页码：217 / 224

页数：8

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