Merkel Cell Carcinoma: A Review

被引:0
作者
Oram, Christian W. [1 ]
Bartus, Cynthia L. [1 ]
Purcell, Stephen M. [1 ]
机构
[1] Philadelphia Coll Osteopath Med, Lehigh Valley Hlth Network, Dermatol Program, Allentown, PA USA
来源
CUTIS | 2016年 / 97卷 / 04期
关键词
POLYOMAVIRUS; INVOLVEMENT;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of unknown origin that usually presents in the elderly population. A novel polyomavirus has been associated with a large percentage of tumors. Immune response plays an important role in pathogenesis of MCC. This article reviews the history, pathogenesis, presentation, and treatment of MCC. Future treatments also are discussed briefly.
引用
收藏
页码:290 / 295
页数:6
相关论文
共 22 条
  • [1] The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma
    Amber, Kyle
    McLeod, Michael P.
    Nouri, Keyvan
    [J]. DERMATOLOGIC SURGERY, 2013, 39 (02) : 232 - 238
  • [2] Angermeyer S, 2013, J INVEST DERMATOL, V133, P1
  • [3] [Anonymous], NCCN CLIN PRACTICE G
  • [4] Survivin Is a Therapeutic Target in Merkel Cell Carcinoma
    Arora, Reety
    Shuda, Masahiro
    Guastafierro, Anna
    Feng, Huichen
    Toptan, Tuna
    Tolstov, Yanis
    Normolle, Daniel
    Vollmer, Laura L.
    Vogt, Andreas
    Doemling, Alexander
    Brodsky, Jeffrey L.
    Chang, Yuan
    Moore, Patrick S.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (133)
  • [5] Immunobiology of Merkel Cell Carcinoma: Implications for Immunotherapy of a Polyomavirus-Associated Cancer
    Bhatia, Shailender
    Afanasiev, Olga
    Nghiem, Paul
    [J]. CURRENT ONCOLOGY REPORTS, 2011, 13 (06) : 488 - 497
  • [6] The predictive value of imaging studies in evaluating regional lymph node involvement in Merkel cell carcinoma
    Colgan, Michael B.
    Tarantola, Tina I.
    Weaver, Amy L.
    Wiseman, Gregory A.
    Roenigk, Randall K.
    Brewer, Jerry D.
    Otley, Clark C.
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 67 (06) : 1250 - 1256
  • [7] Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen
    Demetriou, Stephanie K.
    Ona-Vu, Katherine
    Sullivan, Erin M.
    Dong, Tiffany K.
    Hsu, Shu-Wei
    Oh, Dennis H.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (08) : 1818 - 1827
  • [8] DEWOLFPEETERS C, 1980, CANCER, V46, P1810, DOI 10.1002/1097-0142(19801015)46:8<1810::AID-CNCR2820460819>3.0.CO
  • [9] 2-7
  • [10] Recent Advances in the Understanding of the Genetics, Etiology, and Treatment of Merkel Cell Carcinoma
    Donepudi, Sreekanth
    DeConti, Ronald C.
    Samlowski, Wolfram E.
    [J]. SEMINARS IN ONCOLOGY, 2012, 39 (02) : 163 - 172