Biofunctionalization of gold nanorods

被引：18

作者：

Hwang, Sung-Yeon ^{[1
]}

Tao, Andrea R. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA

来源：

PURE AND APPLIED CHEMISTRY | 2011年 / 83卷 / 01期

关键词：

biosensing; biotechnology; metals; nanoparticles; nanorods; surface modification; SURFACE-PLASMON RESONANCE; PHOTOTHERMAL THERAPY; NANOPARTICLES; GROWTH; SHAPE; DNA; ABSORPTION; SIMULATION; MECHANISM;

D O I：

10.1351/PAC-CON-10-09-35

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanorods (NRs) are promising nanomaterials for biotechnology innovations that include photoassisted drug delivery, gene therapy, noninvasive cancer detection, and ultrasensitive biodetection. Owing to their unique geometry, Au NRs exhibit surface plasmon (SP) modes in the near-infrared (IR) wavelength range-ideal for carrying out optical measurements in biological fluids and tissue. Because NR interactions highly depend on the chemical nature of their solvent-accessible interface, it is necessary to carry out specific post-synthetic chemical modifications of the Au surface to create NRs that are biocompatible and biofunctional. In this review, we discuss various NR surface chemistries that have successfully enabled the integration of Au NRs into biological environments, as well as current challenges in designing the biofunctional NR interface for in vivo applications.

引用

页码：233 / 241

页数：9

共 46 条

[1] Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects [J].

Alkilany, Alaaldin M. ;

Nagaria, Pratik K. ;

Hexel, Cole R. ;

Shaw, Timothy J. ;

Murphy, Catherine J. ;

Wyatt, Michael D. .

SMALL, 2009, 5 (06) :701-708

[2] FORMATION OF MONOLAYER FILMS BY THE SPONTANEOUS ASSEMBLY OF ORGANIC THIOLS FROM SOLUTION ONTO GOLD [J].

BAIN, CD ;

TROUGHTON, EB ;

TAO, YT ;

EVALL, J ;

WHITESIDES, GM ;

NUZZO, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (01) :321-335

[3] Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles [J].

Cedervall, Tommy ;

Lynch, Iseult ;

Lindman, Stina ;

Berggard, Tord ;

Thulin, Eva ;

Nilsson, Hanna ;

Dawson, Kenneth A. ;

Linse, Sara .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (07) :2050-2055

[4] DNA-gold nanorod conjugates for remote control of localized gene expression by near infrared irradiation [J].

Chen, CC ;

Lin, YP ;

Wang, CW ;

Tzeng, HC ;

Wu, CH ;

Chen, YC ;

Chen, CP ;

Chen, LC ;

Wu, YC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (11) :3709-3715

[5] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].

Connor, EE ;

Mwamuka, J ;

Gole, A ;

Murphy, CJ ;

Wyatt, MD .

SMALL, 2005, 1 (03) :325-327

[6] Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice [J].

Dickerson, Erin B. ;

Dreaden, Erik C. ;

Huang, Xiaohua ;

El-Sayed, Ivan H. ;

Chu, Hunghao ;

Pushpanketh, Sujatha ;

McDonald, John F. ;

El-Sayed, Mostafa A. .

CANCER LETTERS, 2008, 269 (01) :57-66

[7] Enhancement of sensitivity using gold nanorods-Antibody conjugator for detection of E. coli O157:H7 [J].

Eum, Nyeon-Sik ;

Yeom, Se-Hyuk ;

Kwon, Dae-Hyuk ;

Kim, Hak-Rin ;

Kang, Shin-Won .

SENSORS AND ACTUATORS B-CHEMICAL, 2010, 143 (02) :784-788

[8] Cancer nanotechnology: Opportunities and challenges [J].

Ferrari, M .

NATURE REVIEWS CANCER, 2005, 5 (03) :161-171

[9]

GANS R, 1915, ANN PHYS, P270

[10] Tailoring the polyelectrolyte coating of metal nanoparticles [J].

Gittins, DI ;

Caruso, F .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (29) :6846-6852

← 1 2 3 4 5 →