The role of oxygen in the antiviral activity of hypericin and hypocrellin

被引：51

作者：

Park, J

English, DS

Wannemuehler, Y

Carpenter, S ^{[1
]}

Petrich, JW

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

[2] Iowa State Univ, Dept Microbiol Immunol & Prevent Med, Ames, IA 50011 USA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1998年 / 68卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1998.tb02519.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The light-induced antiviral activity of hypericin and hypocrellin in the presence and absence of oxygen was examined under experimental conditions where the effect of oxygen depletion could be quantified. There was a significant reduction of light-induced antiviral activity of hypericin and hypocrellin under hypoxic conditions. Interestingly, antiviral activity of hypocrellin was not observed at low oxygen levels at which hypericin retained measurable virucidal activity. This suggests that additional pathways, such as the generation of protons from excited states of hypericin, may enhance the biological activity of activated oxygen species.

引用

页码：593 / 597

页数：5

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