Determination of the enantiomeric composition of ibuprofen solutions via a rapid and sensitive mass spectrometry method

被引：21

作者：

Augusti, DV ^{[1
]}

Augusti, R ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 10期

关键词：

D O I：

10.1016/j.tetasy.2005.04.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A rapid and sensitive method for the determination of the enantiomeric composition of ibuprofen solutions is presented. This approach uses electrospray ionization tandem mass spectrometry and applies the kinetic method to perform the data analysis. Deviations of ca. 1.5% between the actual and experimental enantiomeric composition were observed. The simplicity, sensitivity, and precision of the method make it potentially suitable for the quantification of ibuprofen enantiomers in biological samples. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1881 / 1885

页数：5

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