Prenylated chalcones isolated from Crotalaria genus inhibits in vitro growth of the human malaria parasite Plasmodium falciparum

被引：92
作者：
Narender, T [1 ]
Shweta
Tanvir, K
Rao, MS
Srivastava, K
Puri, SK
机构：
[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
[3] Univ Rhode Isl, Dept Biomed Sci, Kingston, RI 02881 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 10期
关键词：
prenylated chalcone; Plasmodium falciparum; antimalarial activity;
D O I：
10.1016/j.bmcl.2005.03.081
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A prenylated chalcone 2 named crotaorixin, has been isolated from the aerial parts of the Crotalaria orixensis. Its structure has been established by extensive 1D and 2D NMR measurements. In vitro antimalarial activity of crotaorixin as well as few prenylated chalcones isolated from C. medicagenia and C. ramosissima were evaluated at three concentrations (50, 10 and 2 mu g/ml) against Plasmodium fulciparum (Strain NF-54). Compound 3 has exhibited 100% inhibition of schizont maturation at 2 mu g/ml concentration. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：2453 / 2455
页数：3
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