Immunogenicity and Safety of the Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV) in Patients with Malignancy

被引：64

作者：

Ariamanesh, Mona ^{[1
]}

Porouhan, Pejman ^{[2
]}

PeyroShabany, Babak ^{[3
]}

Fazilat-Panah, Danial ^{[4
]}

Dehghani, Mansoureh ^{[5
]}

Nabavifard, Maryam ^{[6
]}

Hatami, Farbod ^{[7
]}

Fereidouni, Mohammad ^{[8
]}

Welsh, James S. ^{[9
,10
]}

Javadinia, Seyed Alireza ^{[6
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran

[2] Sabzevar Univ Med Sci, Vasee Hosp, Dept Radiat Oncol, Sabzevar, Iran

[3] Sabzevar Univ Med Sci, Dept Internal Med, Sabzevar, Iran

[4] Babol Univ Med Sci, Canc Res Ctr, Babol, Iran

[5] Neyshabur Univ Med Sci, Neyshabur, Iran

[6] Sabzevar Univ Med Sci, Hosp Res Dev Comm, Clin Res Dev Unit, TohidShar BLV, Sabzevar 9617747431, Razavi Khorasan, Iran

[7] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, Iran

[8] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[9] Edward Hines Jr VA Hosp, Dept Radiat Oncol, Chicago, IL USA

[10] Loyola Univ, Stritch Sch Med, Chicago, IL 60611 USA

来源：

CANCER INVESTIGATION | 2022年 / 40卷 / 01期

关键词：

COVID-19; SARS-CoV-2; vaccines; cancer patients; anticancer treatment; Malignancy; COVID-19;

D O I：

10.1080/07357907.2021.1992420

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective To evaluate the safety and immunogenicity of the inactivated SARS-CoV-2 vaccine in cancer patients. Material and method 364 cancer patients who received two doses of vaccine were enrolled. The presence of SARS-CoV-2 anti-Spike protein IgG and neutralizing antibody 2 months following vaccination were measured by ELIZA. Results Injection site pain and fever were the most common local and systemic side effects. The overall seroconversion rate was 86.9% that was lower in older age, those with hematological malignancies and chemotherapy receivers. Conclusion The result of study confirmed the safety and short-term efficacy of inactivated vaccine in patients with malignancies.

引用

页码：26 / 34

页数：9

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