TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

被引：1000
|
作者：
Morikawa, Masato [1 ]
Derynck, Rik [2 ]
Miyazono, Kohei [3 ]
机构：
[1] Uppsala Univ, Biomed Ctr, Sci Life Lab, Ludwig Canc Res, SE-75124 Uppsala, Sweden
[2] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA
[3] Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Bunkyo Ku, Tokyo 1130033, Japan
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2016年 / 8卷 / 05期
关键词：
TRANSFORMING-GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; EMBRYONIC STEM-CELLS; CAMURATI-ENGELMANN-DISEASE; ERYTHROID-DIFFERENTIATION FACTOR; MULLERIAN HORMONE-RECEPTOR; LATENCY-ASSOCIATED PEPTIDE; DOMAIN-SPECIFIC MUTATIONS; INDUCED LUNG FIBROSIS; REGULATORY T-CELLS;
D O I：
10.1101/cshperspect.a021873
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The transforming growth factor-beta (TGF-beta) is the prototype of the TGF-beta family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-beta family with its complexity of names and biological activities. It also introduces TGF-beta as the best-studied factor among the TGF-beta family proteins, with its diversity of roles in the control of cell proliferation and differentiation, wound healing and immune system, and its key roles in pathology, for example, skeletal diseases, fibrosis, and cancer.
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页数：24
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