A superfamily of proteins that contain the cold-shock domain

被引:369
作者
Graumann, PL [1 ]
Marahiel, MA
机构
[1] Harvard Univ, Biol Labs, Cambridge, MA 02138 USA
[2] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany
关键词
D O I
10.1016/S0968-0004(98)01255-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Members of a family of cold-shock proteins (CSPs) are found throughout the eubacterial domain and appear to function as RNA-chaperones. They have been implicated in various cellular processes, including adaptation to low temperatures, cellular growth, nutrient stress and stationary phase. The discovery of a domain - the cold-shock domain - that shows strikingly high homology and similar RNA-binding properties to CSPs in a growing number of eukaryotic nucleic-acid-binding proteins suggests that these proteins have an ancient origin.
引用
收藏
页码:286 / 290
页数:5
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