Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids

被引：13

作者：

Cao, Yue ^{[1
,2
]}

Han, Shenghua ^{[2
]}

Zhang, Han ^{[3
]}

Wang, Jie ^{[1
]}

Jiang, Qiao-Yan ^{[1
]}

Zhou, Yimin ^{[2
]}

Yu, You-Jia ^{[1
]}

Wang, Jianfang ^{[3
]}

Chen, Feng ^{[1
]}

Ng, Dennis K. P. ^{[2
]}

机构：

[1] Nanjing Med Univ, Dept Forens Med, Nanjing 211166, Jiangsu, Peoples R China

[2] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Dept Phys, Shatin, Hong Kong, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 29期

基金：

中国国家自然科学基金;

关键词：

TISSUES;

D O I：

10.1039/d1tb01274f

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acids on the surface of cancer cells based on its dual surface-enhanced Raman scattering and fluorescence response. This biomarker can also trigger the photodynamic activity of these nanobipyramids, effectively eradicating the cancer cells mainly through apoptosis as shown by various bioassays.

引用

页码：5780 / 5784

页数：5

共 40 条

[1] SERS-fluorescent encoded particles as dual-mode optical probes [J].

Alvarez-Puebla, Ramon A. ;

Pazos-Perez, Nicolas ;

Guerrini, Luca .

APPLIED MATERIALS TODAY, 2018, 13 :1-14

[2] Sialic acids in biological and therapeutic processes: opportunities and challenges [J].

Bauer, Julia ;

Osborn, Helen M. I. .

FUTURE MEDICINAL CHEMISTRY, 2015, 7 (16) :2285-2299

[3] Sialic Acids Sweeten a Tumor's Life [J].

Bull, Christian ;

Stoel, Marieke A. ;

den Brok, Martijn H. ;

Adema, Gosse J. .

CANCER RESEARCH, 2014, 74 (12) :3199-3204

[4] Gold NanoBipyramids Performing as Highly Sensitive Dual-Modal Optical Immunosensors [J].

Campu, Andreea ;

Lerouge, Frederic ;

Chateau, Denis ;

Chaput, Frederic ;

Baldeck, Patrice ;

Parola, Stephane ;

Maniu, Dana ;

Craciun, Ana Maria ;

Vulpoi, Adriana ;

Astilean, Simion ;

Focsan, Monica .

ANALYTICAL CHEMISTRY, 2018, 90 (14) :8567-8575

[5] Raman/fluorescence dual-sensing and imaging of intracellular pH distribution [J].

Cao, Yue ;

Qian, Ruo-Can ;

Li, Da-Wei ;

Long, Yi-Tao .

CHEMICAL COMMUNICATIONS, 2015, 51 (99) :17584-17587

[6] Assays for the identification and quantification of sialic acids: Challenges, opportunities and future perspectives [J].

Cheeseman, Jack ;

Kuhnle, Gunter ;

Spencer, Daniel I. R. ;

Osborn, Helen M. I. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 30

[7] Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine [J].

Cheng, Wei ;

Zeng, Xiaowei ;

Chen, Hongzhong ;

Li, Zimu ;

Zeng, Wenfeng ;

Mei, Lin ;

Zhao, Yanli .

ACS NANO, 2019, 13 (08) :8537-8565

[8] Gold Nanobipyramids: An Emerging and Versatile Type of Plasmonic Nanoparticles [J].

Chow, Tsz Him ;

Li, Nannan ;

Bai, Xiaopeng ;

Zhuo, Xiaolu ;

Shao, Lei ;

Wang, Jianfang .

ACCOUNTS OF CHEMICAL RESEARCH, 2019, 52 (08) :2136-2146

[9] Distinguishing cancer cell lines at asingle living cell level via detection of sialic acid by dual-channel plasmonic imaging and by using a SERS-microfluidic droplet platform [J].

Cong, Lili ;

Liang, Lijia ;

Cao, Fanghao ;

Sun, Dan ;

Yue, Jing ;

Xu, Weiqing ;

Liang, Chongyang ;

Xu, Shuping .

MICROCHIMICA ACTA, 2019, 186 (06)

[10] Immobilising hairpin DNA-conjugated distyryl boron dipyrromethene on gold@polydopamine core-shell nanorods for microRNA detection and microRNA-mediated photodynamic therapy† [J].

Dai, Gaole ;

Choi, Chun Kit K. ;

Zhou, Yimin ;

Bai, Qianqian ;

Xiao, Yu ;

Yang, Caixia ;

Choi, Chung Hang Jonathan ;

Ng, Dennis K. P. .

NANOSCALE, 2021, 13 (13) :6499-6512

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