Paying the price for pathogen protection: toll receptors in atherogenesis

被引：93

作者：

Tobias, P ^{[1
]}

Curtiss, LK ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

JOURNAL OF LIPID RESEARCH | 2005年 / 46卷 / 03期

关键词：

macrophage; lipopolysaccharide; peptidoglycan; inflammation; mouse model;

D O I：

10.1194/jlr.R400015-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis is a chronic inflammatory response characterized by the accumulation of cells of innate and acquired immune systems within the intima of the arterial wall. Macrophages are the predominant participant in innate immune responses in atherosclerosis. Protein receptors expressed by macrophages and endothelial cells recognize components and products of microorganisms and play a vital role in innate immunity. In particular, the members of the toll-like receptor (TLR) family play a critical role in the inflammatory components of atherosclerosis. Both exogenous ligands involved in microbial recognition as well as endogenous ligands involved in sterile inflammation pathways are implicated in the pathology of atherosclerosis. In this review, we discuss our current understanding of the role of TLRs and their coactivators in atherosclerosis, with particular emphasis on studies in atherosclerosis-prone hypercholesterolemic mice.

引用

页码：404 / 411

页数：8

共 93 条

[1] Cutting edge: Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages [J].

Akashi, S ;

Shimazu, R ;

Ogata, H ;

Nagai, Y ;

Takeda, K ;

Kimoto, M ;

Miyake, K .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3471-3475

[2] Functions of Toll-like receptors: lessons from KO mice [J].

Akira, S ;

Takeda, K .

COMPTES RENDUS BIOLOGIES, 2004, 327 (06) :581-589

[3] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[4] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[5] Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses [J].

Beg, AA .

TRENDS IN IMMUNOLOGY, 2002, 23 (11) :509-512

[6] Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2 [J].

Biragyn, A ;

Ruffini, PA ;

Leifer, CA ;

Klyushnenkova, E ;

Shakhov, A ;

Chertov, O ;

Shirakawa, AK ;

Farber, JM ;

Segal, DM ;

Oppenheim, JJ ;

Kwak, LW .

SCIENCE, 2002, 298 (5595) :1025-1029

[7] Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways [J].

Björkbacka, H ;

Kunjathoor, VV ;

Moore, KJ ;

Koehn, S ;

Ordija, CM ;

Lee, MA ;

Means, T ;

Halmen, K ;

Luster, AD ;

Golenbock, DT ;

Freeman, MW .

NATURE MEDICINE, 2004, 10 (04) :416-421

[8] Mouse models of atherosclerosis [J].

Breslow, JL .

SCIENCE, 1996, 272 (5262) :685-688

[9] ATHEROMA - NEW HYPOTHESIS [J].

CARO, CG ;

FITZGERA.JM ;

SCHROTER, RC .

BRITISH MEDICAL JOURNAL, 1971, 2 (5762) :651-&

[10] Human cytomegalovirus activates inflammatory cytokine responses via CD14 and toll-like receptor 2 [J].

Compton, T ;

Kurt-Jones, EA ;

Boehme, KW ;

Belko, J ;

Latz, E ;

Golenbock, DT ;

Finberg, RW .

JOURNAL OF VIROLOGY, 2003, 77 (08) :4588-4596

← 1 2 3 4 5 6 7 8 9 10 →