Fabrication and properties of a porous chitin/chitosan conduit for nerve regeneration

被引：68

作者：

Yang, YM ^{[1
]}

Gu, XS

Tan, RX

Hu, W

Wang, XD

Zhang, PY

Zhang, TY

机构：

[1] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210093, Peoples R China

[2] Nantong Med Coll, Jiagsu Prov Key Lab Neuroregenerat, Jiangsu 226001, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2004年 / 26卷 / 23期

关键词：

chitin; chitosan; nerve conduit; nerve regeneration;

D O I：

10.1007/s10529-004-4611-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A porous, biodegradable, natural chitin/chitosan nerve conduit was constructed. Scanning electron microscopy confirmed that it was homogeneous and highly porous. FT-IR spectra showed that there were no residues arising from the preparation process in the conduit. Addition of chitin to the chitosan solution increased the mechanical strength and maximum tensile strength from 7.2 to 9.6 MPa. Preliminary animal tests indicated that porous chitin/chitosan conduits did not swell in vivo and were compatible with surrounding tissue.

引用

页码：1793 / 1797

页数：5

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