How low can you go? Achieved blood pressure and cardiovascular outcomes

被引:2
作者
Wyatt, Christina M. [1 ]
Cheung, Alfred K. [2 ,3 ,4 ]
机构
[1] Icahn Sch Med Mt Sinai, Div Nephrol, Dept Med, New York, NY 10029 USA
[2] Univ Utah, Div Nephrol & Hypertens, Salt Lake City, UT USA
[3] Vet Affairs Salt Lake City Healthcare Syst, Med Serv, Salt Lake City, UT USA
[4] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Hunan, Peoples R China
关键词
cardiovascular disease; congestive heart failure;
D O I
10.1016/j.kint.2017.07.002
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The benefits of controlling blood pressure to levels < 140/90 mm Hg are well established, but the risks and benefits of further reductions in blood pressure are less clear. A recent observational study using pooled data from 2 large randomized trials of renin-angiotensin system blockers suggested no added benefit and some increased risk of cardiovascular events with achieved blood pressures < 120 mm Hg systolic or 70 mm Hg diastolic. Caveats of observational studies notwithstanding, these results add to the ongoing controversy over the optimal blood pressure target for high-risk individuals.
引用
收藏
页码:536 / +
页数:5
相关论文
共 9 条
  • [1] Adamsson Eyrd S, 2016, BMJ-BRIT MED J, V354, pi4070
  • [2] Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials
    Boehm, Michael
    Schumacher, Helmut
    Teo, Koon K.
    Lonn, Eva M.
    Mahfoud, Felix
    Mann, Johannes F. E.
    Mancia, Giuseppe
    Redon, Josep
    Schmieder, Roland E.
    Sliwa, Karen
    Weber, Michael A.
    Williams, Bryan
    Yusuf, Salim
    [J]. LANCET, 2017, 389 (10085) : 2226 - 2237
  • [3] Bundy JD., JAMA Cardiol
  • [4] Kidney Disease j Improving Social Outcomes, KDIGO CONTR C BLOOD
  • [5] Global Disparities of Hypertension Prevalence and Control A Systematic Analysis of Population-Based Studies From 90 Countries
    Mills, Katherine T.
    Bundy, Joshua D.
    Kelly, Tanika N.
    Reed, Jennifer E.
    Kearney, Patricia M.
    Reynolds, Kristi
    Chen, Jing
    He, Jiang
    [J]. CIRCULATION, 2016, 134 (06) : 441 - +
  • [6] A Randomized Trial of Intensive versus Standard Blood-Pressure Control
    Wright, Jackson T., Jr.
    Williamson, Jeff D.
    Whelton, Paul K.
    Snyder, Joni K.
    Sink, Kaycee M.
    Rocco, Michael V.
    Reboussin, David M.
    Rahman, Mahboob
    Oparil, Suzanne
    Lewis, Cora E.
    Kimmel, Paul L.
    Johnson, Karen C.
    Goff, David C., Jr.
    Fine, Lawrence J.
    Cutler, Jeffrey A.
    Cushman, William C.
    Cheung, Alfred K.
    Ambrosius, Walter T.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (22) : 2103 - 2116
  • [7] Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: an international cohort study
    Vidal-Petiot, Emmanuelle
    Ford, Ian
    Greenlaw, Nicola
    Ferrari, Roberto
    Fox, Kim M.
    Tardif, Jean-Claude
    Tendera, Michal
    Tavazzi, Luigi
    Bhatt, Deepak L.
    Steg, Philippe Gabriel
    [J]. LANCET, 2016, 388 (10056) : 2142 - 2152
  • [8] Clinical trials of intensive versus less intensive control of hypertension: HOPE or HYPE?
    Wyatt, Christina M.
    Chertow, Glenn M.
    [J]. KIDNEY INTERNATIONAL, 2016, 90 (03) : 460 - 465
  • [9] Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis
    Xie, Xinfang
    Atkins, Emily
    Lv, Jicheng
    Bennett, Alexander
    Neal, Bruce
    Ninomiya, Toshiharu
    Woodward, Mark
    MacMahon, Stephen
    Turnbull, Fiona
    Hillis, Graham S.
    Chalmers, John
    Mant, Jonathan
    Salam, Abdul
    Rahimi, Kazem
    Perkovic, Vlado
    Rodgers, Anthony
    [J]. LANCET, 2016, 387 (10017) : 435 - 443