Syndrome of impaired tolerance to dietary fats in coronary heart disease

Changes of main lipid and apolipoprotein parameters of lipid transport system during postprandial hyperlipidemia were studied in subjects without (n = 72) and with (n = 167) overt coronary heart disease (CHD) including patients with noninsulin dependent diabetes (n = 48). Tolerance to dietary fat was evaluated by oral fat load test (consumption of 639 +/- 7 ml of 20% cream after fast). in subjects without CHD reaction of lipid transport system to fat load was characterized by lowered total, low density lipoprotein cholesterol, apolipoprotein apo B and apo B/apo A-1 ratio, lowered or unchanged triglycerides, stable high density lipoprotein cholesterol level at the background of apo A-1 elevation by 6-th hour after load. Patients with CHID exhibited signs of impaired tolerance to dietary fat: elevation of triglycerides, apo B and apo B/apo A-1 ratio, lowering of high density lipoprotein cholesterol, increase of percentage of subfractions of small high density lipoproteins particles, increase of triglyceride content in low and-high density lipoprotein fraction during 6 hours after fat load.