A dual channel optical sensor for biliverdin and bilirubin using glutathione capped copper nanoclusters

被引：19
作者：
Anand, Sanu K. [1 ]
Mathew, Manna Rachel [1 ]
Kumar, K. Girish [1 ]
机构：
[1] Cochin Univ Sci & Technol, Dept Appl Chem, Kochi, Kerala, India
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2021年 / 418卷
关键词：
Biliverdin; Bilirubin; Copper nanoclusters; Static quenching; Fluorescence; Colorimetry; FLUORESCENT METAL NANOCLUSTERS; SELECTIVE DETECTION; SERUM; PROBE; DOTS;
D O I：
10.1016/j.jphotochem.2021.113379
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A simple, highly selective and cost-effective colorimetric as well as fluorimetric sensor for the bile pigments, biliverdin (BVD) and bilirubin (BLR) has been developed using glutathione stabilized copper nanoclusters (GSHCuNCs). Sensing has been achieved via the formation of a non-fluorescent ground state complex between the nanoprobe and analytes. Different sensor parameters were optimized and under these conditions, highly sensitive determination of BVD/BLR in wide linear ranges has been obtained in a dual responsive manner. Practical utility of the developed sensor has also been demonstrated in synthetic physiological fluids.
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