(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses

被引：12

作者：

Filimonov, Aleksandr S. ^{[1
]}

Yarovaya, Olga, I ^{[1
]}

Zaykovskaya, Anna, V ^{[2
]}

Rudometova, Nadezda B. ^{[2
]}

Shcherbakov, Dmitriy N. ^{[2
]}

Chirkova, Varvara Yu ^{[3
]}

Baev, Dmitry S. ^{[1
]}

Borisevich, Sophia S. ^{[4
]}

Luzina, Olga A. ^{[1
]}

Pyankov, Oleg, V ^{[2
]}

Maksyutov, Rinat A. ^{[2
]}

Salakhutdinov, Nariman F. ^{[1
]}

机构：

[1] NN Vorozhtsov Novosibirsk Inst Organ Chem SB RAS, Dept Med Chem, Novosibirsk 630090, Russia

[2] State Res Ctr Virol & Biotechnol VECTOR, Ekaterinburg 630559, Russia

[3] Altay State Univ, Dept Phys Chem Biol & Biotechnol, Barnaul 656049, Russia

[4] Ufa Fed Res Ctr, Lab Chem Phys, Ufa Inst Chem, Ufa 450078, Russia

来源：

VIRUSES-BASEL | 2022年 / 14卷 / 10期

基金：

俄罗斯科学基金会;

关键词：

usnic acid; virus SARS-CoV-2; main viral protease 3CLPro; surface glycoprotein S; molecular modeling; antiviral compound; USNIC ACID; IN-VITRO;

D O I：

10.3390/v14102154

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In order to test the antiviral activity, a series of usnic acid derivatives were synthesized, including new, previously undescribed compounds. The activity of the derivatives against three strains of SARS-CoV-2 virus was studied. To understand the mechanism of antiviral action, the inhibitory activity of the main protease of SARS-CoV-2 virus was studied using the developed model as well as the antiviral activity against the pseudoviral system with glycoprotein S of SARS-CoV-2 virus on its surface. It was shown that usnic acid exhibits activity against three strains of SARS-CoV-2 virus: Wuhan, Delta, and Omicron. Compounds 10 and 13 also showed high activity against the three strains. The performed biological studies and molecular modeling allowed us to assume that the derivatives of usnic acid bind in the N-terminal domain of the surface glycoprotein S at the binding site of the hemoglobin decay metabolite.

引用

页数：21

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