Local field radiotherapy without elective nodal irradiation for postoperative loco-regional recurrence of esophageal cancer

被引:11
作者
Kimoto, Takuya [1 ]
Yamazaki, Hideya [1 ]
Suzuki, Gen [1 ]
Aibe, Norihiro [1 ]
Masui, Koji [1 ]
Tatekawa, Kotoha [1 ]
Sasaki, Naomi [1 ]
Fujiwara, Hitoshi [2 ]
Shiozaki, Atsushi [2 ]
Konishi, Hirotaka [2 ]
Nakamura, Satoaki [3 ]
Yamada, Kei [1 ]
机构
[1] Kyoto Prefectural Univ Med, Dept Radiol, Kyoto, Japan
[2] Kyoto Prefectural Univ Med, Dept Digest Surg, Grad Sch Med Sci, Kamigyo Ku, Kyoto, Japan
[3] Kansai Med Univ, Dept Radiol, Hirakata, Osaka, Japan
关键词
esophageal cancer; postoperative recurrence; loco-regional recurrence; radiotherapy; SQUAMOUS-CELL CARCINOMA; EXTENDED RADICAL ESOPHAGECTOMY; RADIATION-THERAPY; CURATIVE RESECTION; THORACIC ESOPHAGUS; PHASE-II; CONCURRENT CHEMORADIOTHERAPY; LOCOREGIONAL RECURRENCE; CHEMORADIATION THERAPY; PERICARDIAL-EFFUSION;
D O I
10.1093/jjco/hyx092
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Radiotherapy is an effective treatment for the postoperative loco-regional recurrence of esophageal cancer; however, the optimal treatment field remains controversial. This study aims to evaluate the outcome of local field radiotherapy without elective nodal irradiation for postoperative loco-regional recurrence of esophageal cancer. Methods: We retrospectively investigated 35 patients treated for a postoperative loco-regional recurrence of esophageal cancer with local field radiotherapy between December 2008 and March 2016. The median irradiation dose was 60 Gy (range: 50-67.5 Gy). Thirty-one (88.6%) patients received concurrent chemotherapy. Results: The median follow-up period was 18 months (range: 5-94 months). The 2-year overall survival was 55.7%, with a median survival time of 29.9 months. In the univariate analysis, the maximal diameter <20mm (P = 0.0383), solitary lesion (P = 0.0352), and the complete remission after treatment (P = 0.00411) had a significantly better prognosis. A total of 27 of 35 patients (77.1%) had progressive disease (loco-regional failure [n = 9], distant metastasis [n = 7], and both loco-regional failure and distant metastasis [n = 11]). No patients had Grade 3 or greater mucositis. Conclusion: Local field radiotherapy is a considerable treatment option for postoperative locoregional recurrence of esophageal cancer.
引用
收藏
页码:809 / 814
页数:6
相关论文
共 38 条
  • [1] Analysis of dose-volume histogram parameters for radiation pneumonitis after definitive concurrent chemoradiotherapy for esophageal cancer
    Asakura, Hirofumi
    Hashimoto, Takayuki
    Zenda, Sadamoto
    Harada, Hideyuki
    Hirakawa, Koichi
    Mizumoto, Masashi
    Furutani, Kazuhisa
    Hironaka, Shuichi
    Fuji, Hiroshi
    Murayama, Shigeyuki
    Boku, Narikazu
    Nishimura, Tetsuo
    [J]. RADIOTHERAPY AND ONCOLOGY, 2010, 95 (02) : 240 - 244
  • [2] Three-dimensional conformal radiotherapy with concurrent chemotherapy for postoperative recurrence of esophageal squamous cell carcinoma: clinical efficacy and failure pattern
    Bao, Yong
    Liu, ShiLiang
    Zhou, QiChao
    Cai, PeiQiang
    Anfossi, Simone
    Li, QiaoQiao
    Hu, YongHong
    Liu, MengZhong
    Fu, JianHua
    Rong, TieHua
    Li, Qun
    Liu, Hui
    [J]. RADIATION ONCOLOGY, 2013, 8
  • [3] Pattern of recurrence after extended radical esophagectomy with three-field lymph node dissection for squamous cell carcinoma in the thoracic esophagus
    Bhansali, MS
    Fujita, H
    Kakegawa, T
    Yamana, H
    Ono, T
    Hikita, S
    Toh, Y
    Fujii, T
    Tou, U
    Shirouzu, K
    [J]. WORLD JOURNAL OF SURGERY, 1997, 21 (03) : 275 - 281
  • [4] Recurrence pattern of squamous cell carcinoma in the middle thoracic esophagus after modified ivor-lewis esophagectomy
    Chen, Gang
    Wang, Zhou
    Liu, Xiang-yan
    Liu, Fan-ying
    [J]. WORLD JOURNAL OF SURGERY, 2007, 31 (05) : 1107 - 1114
  • [5] Pattern of recurrence following radical oesophagectomy with two-field lymphadenectomy
    Dresner, SM
    Griffin, SM
    [J]. BRITISH JOURNAL OF SURGERY, 2000, 87 (10) : 1426 - 1433
  • [6] Predictive factors for pericardial effusion identified by heart dose-volume histogram analysis in oesophageal cancer patients treated with chemoradiotherapy
    Hayashi, K.
    Fujiwara, Y.
    Nomura, M.
    Kamata, M.
    Kojima, H.
    Kohzai, M.
    Sumita, K.
    Tanigawa, N.
    [J]. BRITISH JOURNAL OF RADIOLOGY, 2015, 88 (1046)
  • [7] Prognostic Factors for Post-recurrence Survival in Esophageal Squamous Cell Carcinoma Patients with Recurrence after Resection
    Hsu, Po-Kuei
    Wang, Bing-Yen
    Huang, Chien-Sheng
    Wu, Yu-Chung
    Hsu, Wen-Hu
    [J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2011, 15 (04) : 558 - 565
  • [8] Results of radiation therapy combined with nedaplatin (cis-diammine-glycoplatinum) and 5-Fluorouracil for postoperative locoregional recurrent esophageal cancer
    Jingu, K
    Nemoto, K
    Matsushita, H
    Takahashi, C
    Ogawa, Y
    Sugawara, T
    Nakata, E
    Takai, Y
    Yamada, S
    [J]. BMC CANCER, 2006, 6 (1)
  • [9] Long-term results of radiotherapy combined with nedaplatin and 5-fluorouracil for postoperative loco-regional recurrent esophageal cancer: update on a phase II study
    Jingu, Keiichi
    Matsushita, Haruo
    Takeda, Ken
    Umezawa, Rei
    Takahashi, Chiaki
    Sugawara, Toshiyuki
    Kubozono, Masaki
    Abe, Keiko
    Tanabe, Takaya
    Shirata, Yuko
    Yamamoto, Takaya
    Ishikawa, Youjirou
    Nemoto, Kenji
    [J]. BMC CANCER, 2012, 12
  • [10] Long-Term Results of Radiochemotherapy for Solitary Lymph Node Metastasis After Curative Resection of Esophageal Cancer
    Jingu, Keiichi
    Ariga, Hisanori
    Nemoto, Kenji
    Narazaki, Kakutaro
    Umezawa, Rei
    Takeda, Ken
    Koto, Masashi
    Sugawara, Toshiyuki
    Kubozono, Masaki
    Miyata, Go
    Onodera, Ko
    Yamada, Shogo
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 83 (01): : 172 - 177