Cell Response to Carbon Nanotubes: Size-Dependent Intracellular Uptake Mechanism and Subcellular Fate

被引：108
作者：
Kang, Bin [1 ,2 ]
Chang, Shuquan [1 ]
Dai, Yaodong [1 ]
Yu, Decai [3 ]
Chen, Da [1 ]
机构：
[1] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Nanjing 210016, Peoples R China
[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
[3] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Hepatobiliary Surg, Nanjing 210008, Peoples R China
来源：
SMALL | 2010年 / 6卷 / 21期
基金：
中国国家自然科学基金;
关键词：
RECEPTOR-MEDIATED ENDOCYTOSIS; COATED PIT FORMATION; MAMMALIAN-CELLS; TRANSPORTERS; CLATHRIN; INTERNALIZATION; ACCUMULATION; DEPLETION; DELIVERY; AGENTS;
D O I：
10.1002/smll.201001260
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The intracellular uptake and subcellular localization of carbon nanotubes strongly depend on the physical size of the materials. Multiwalled carbon nanotubes (MWNTs; 0.5-2 μm in length, 10-30 nm in diameter) are excluded from the interior of the cell; long single-walled carbon nanotubes (L-SWNTs) of length 100-200 nm (1-3 nm in diameter) are only internalized into cytoplasm, whereas short ones (S-SWNTs) of length 50-100 nm partly reside in the cell nucleus. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2362 / 2366
页数：5
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