Cell Response to Carbon Nanotubes: Size-Dependent Intracellular Uptake Mechanism and Subcellular Fate

被引：110

作者：

Kang, Bin ^{[1
,2
]}

Chang, Shuquan ^{[1
]}

Dai, Yaodong ^{[1
]}

Yu, Decai ^{[3
]}

Chen, Da ^{[1
]}

机构：

[1] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Nanjing 210016, Peoples R China

[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[3] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Hepatobiliary Surg, Nanjing 210008, Peoples R China

来源：

SMALL | 2010年 / 6卷 / 21期

基金：

中国国家自然科学基金;

关键词：

RECEPTOR-MEDIATED ENDOCYTOSIS; COATED PIT FORMATION; MAMMALIAN-CELLS; TRANSPORTERS; CLATHRIN; INTERNALIZATION; ACCUMULATION; DEPLETION; DELIVERY; AGENTS;

D O I：

10.1002/smll.201001260

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intracellular uptake and subcellular localization of carbon nanotubes strongly depend on the physical size of the materials. Multiwalled carbon nanotubes (MWNTs; 0.5-2 μm in length, 10-30 nm in diameter) are excluded from the interior of the cell; long single-walled carbon nanotubes (L-SWNTs) of length 100-200 nm (1-3 nm in diameter) are only internalized into cytoplasm, whereas short ones (S-SWNTs) of length 50-100 nm partly reside in the cell nucleus. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2362 / 2366

页数：5

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