Cell Response to Carbon Nanotubes: Size-Dependent Intracellular Uptake Mechanism and Subcellular Fate

被引：108

作者：

Kang, Bin ^{[1
,2
]}

Chang, Shuquan ^{[1
]}

Dai, Yaodong ^{[1
]}

Yu, Decai ^{[3
]}

Chen, Da ^{[1
]}

机构：

[1] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Nanjing 210016, Peoples R China

[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[3] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Hepatobiliary Surg, Nanjing 210008, Peoples R China

来源：

SMALL | 2010年 / 6卷 / 21期

基金：

中国国家自然科学基金;

关键词：

RECEPTOR-MEDIATED ENDOCYTOSIS; COATED PIT FORMATION; MAMMALIAN-CELLS; TRANSPORTERS; CLATHRIN; INTERNALIZATION; ACCUMULATION; DEPLETION; DELIVERY; AGENTS;

D O I：

10.1002/smll.201001260

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intracellular uptake and subcellular localization of carbon nanotubes strongly depend on the physical size of the materials. Multiwalled carbon nanotubes (MWNTs; 0.5-2 μm in length, 10-30 nm in diameter) are excluded from the interior of the cell; long single-walled carbon nanotubes (L-SWNTs) of length 100-200 nm (1-3 nm in diameter) are only internalized into cytoplasm, whereas short ones (S-SWNTs) of length 50-100 nm partly reside in the cell nucleus. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2362 / 2366

页数：5

共 24 条

[1] Length-dependent uptake of DNA-wrapped single-walled carbon nanotubes
Becker, Matthew L.
Fagan, Jeffrey A.
Gallant, Nathan D.
Bauer, Barry J.
Bajpai, Vardan
Hobbie, Erik K.
Lacerda, Silvia H.
Migler, Kalman B.
Jakupciak, John P.
[J]. ADVANCED MATERIALS, 2007, 19 (07) : 939 - +
[2] Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing
Cai, D
Mataraza, JM
Qin, ZH
Huang, ZP
Huang, JY
Chiles, TC
Carnahan, D
Kempa, K
Ren, ZF
[J]. NATURE METHODS, 2005, 2 (06) : 449 - 454
[3] Protein microarrays with carbon nanotubes as multicolor Raman labels
Chen, Zhuo
Tabakman, Scott M.
Goodwin, Andrew P.
Kattah, Michael G.
Daranciang, Dan
Wang, Xinran
Zhang, Guangyu
Li, Xiaolin
Liu, Zhuang
Utz, Paul J.
Jiang, Kaili
Fan, Shoushan
Dai, Hongjie
[J]. NATURE BIOTECHNOLOGY, 2008, 26 (11) : 1285 - 1292
[4] Reversible Accumulation of PEGylated Single-Walled Carbon Nanotubes in the Mammalian Nucleus
Cheng, Jinping
Fernando, K. A. Shiral
Veca, L. Monica
Sun, Ya-Ping
Lamond, Angus I.
Lam, Yun Wah
Cheng, Shuk Han
[J]. ACS NANO, 2008, 2 (10) : 2085 - 2094
[5] HYPERTONIC MEDIA INHIBIT RECEPTOR-MEDIATED ENDOCYTOSIS BY BLOCKING CLATHRIN-COATED PIT FORMATION
HEUSER, JE
ANDERSON, RGW
[J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (02) : 389 - 400
[6] Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells
Kam, NWS
Jessop, TC
Wender, PA
Dai, HJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (22) : 6850 - 6851
[7] Carbon nanotubes as intracellular transporters for proteins and DNA: An investigation of the uptake mechanism and pathway
Kam, NWS
Liu, ZA
Dai, HJ
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (04) : 577 - 581
[8] Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
Kam, NWS
O'Connell, M
Wisdom, JA
Dai, HJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) : 11600 - 11605
[9] Intracellular uptake, trafficking and subcellular distribution of folate conjugated single walled carbon nanotubes within living cells
Kang, Bin
Yu, De-cai
Chang, Shu-quan
Chen, Da
Dai, Yao-dong
Ding, Yitao
[J]. NANOTECHNOLOGY, 2008, 19 (37)
[10] Biodistribution and accumulation of intravenously administered carbon nanotubes in mice probed by Raman spectroscopy and fluorescent labeling
Kang, Bin
Yu, Decai
Dai, Yaodong
Chang, Shuquan
Chen, Da
Ding, Yitao
[J]. CARBON, 2009, 47 (04) : 1189 - 1192

← 1 2 3 →