Successful allogeneic stem cell transplantation for an adult with refractory anaplastic lymphoma kinase - Positive anaplastic large cell lymphoma

被引：3
作者：
Chen, Chao-Hsun
Chen, Shan-Wen
Shen, Wan-Lin
Chen, Tsai-Yun
Tsao, Chao-Jung
Huang, Wen-Tsung
机构：
[1] Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol, Tainan County, Taiwan
[2] Chi Mei Med Ctr, Dept Pathol, Tainan, Taiwan
[3] Natl Cheng Kung Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Tainan, Taiwan
[4] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 70101, Taiwan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 85卷 / 02期
关键词：
anaplastic large cell lymphoma; Ki-1; lymphoma; ALK; Allogeneic stem cell transplantation;
D O I：
10.1532/IJH97.A10608
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Anaplastic lymphoma kinase (ALK) expression exists in approximately 60% of anaplastic large cell lymphoma (ALCL) cases. Compared with the ALK-negative cases, ALK-positive cases are usually characterized by a good response to chemotherapy and a good prognosis. In the relapsed or refractory ALCL cases, high-dose chemotherapy followed by autologous stem cell transplantation has been widely used as a salvage therapy. However, 40% of patients who received transplants after more than 2 complete remissions eventually experienced disease progression, despite receiving autologous stem cell transplantation. Allogeneic stem cell transplantation has been proposed as a therapeutic option in refractory ALCL cases, but clinical reports of adult patients are rare. Herein, we report the case of an adult with refractory ALK-positive ALCL who was successfully treated with salvage high-dose chemotherapy followed by allogeneic stem cell transplantation.
引用
收藏
页码：105 / 107
页数：3
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