The GABA-B receptor agonist baclofen helps patients with alcohol use disorder: why these findings matter

被引：7

作者：

Leggio, Lorenzo ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Litten, Raye Z. ^{[9
]}

机构：

[1] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, NIH, Baltimore, MD 21224 USA

[2] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, NIH, Bethesda, MD 20892 USA

[3] NIAAA, NIH, Baltimore, MD USA

[4] NIAAA, NIH, Bethesda, MD 20892 USA

[5] NIDA, Medicat Dev Program, Intramural Res Program, NIH, Baltimore, MD 21224 USA

[6] Brown Univ, Ctr Alcohol & Addict Studies, Dept Behav & Social Sci, Sch Publ Hlth, Providence, RI 02912 USA

[7] Johns Hopkins Univ, Sch Med, Dept Med, Div Addict Med, Baltimore, MD 21205 USA

[8] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA

[9] NIAAA, Div Treatment & Recovery, Bethesda, MD USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2021年 / 46卷 / 13期

关键词：

DOUBLE-BLIND; SAFETY;

D O I：

10.1038/s41386-021-01142-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[No abstract available]

引用

页码：2228 / 2229

页数：2

共 50 条

[21] Gaba-B Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism
Silverman, Jill
Pride, Michael
Hayes, Jane
Puhger, Kyle
Crawley, Jacqueline
NEUROPSYCHOPHARMACOLOGY, 2014, 39 : S598 - S598
[22] THE GROWTH-HORMONE RESPONSE TO BACLOFEN IN OBSESSIVE-COMPULSIVE DISORDER - DOES THE GABA-B RECEPTOR MEDIATE OBSESSIVE ANXIETY
LUCEY, JV
BUTCHER, G
OFLYNN, K
CLARE, AW
DINAN, G
PHARMACOPSYCHIATRY, 1994, 27 (01) : 23 - 26
[23] ROLE OF BACLOFEN IN THE TREATMENT OF ALCOHOL USE DISORDER: RECENT FINDINGS
Leggio, L.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2016, 40 : 275A - 275A
[24] Effects of GABA-B agonist baclofen on bronchial hyperreactivity to inhaled histamine in subjects with cervical spinal cord injury
Grimm, DR
DeLuca, RV
Lesser, M
Bauman, WA
Almenoff, PL
LUNG, 1997, 175 (05) : 333 - 341
[25] Baclofen in the treatment of alcohol use disorder: tailored doses matter
de Beaurepaire, Renaud
Jaury, Philippe
ALCOHOL AND ALCOHOLISM, 2024, 59 (02):
[26] Effects of GABA-B Agonist Baclofen on Bronchial Hyperreactivity to Inhaled Histamine in Subjects with Cervical Spinal Cord Injury
D. R. Grimm
R. V. DeLuca
M. Lesser
W. A. Bauman
P. L. Almenoff
Lung , 1997, 175 : 333 - 341
[27] POST-TRAINING SYSTEMIC AND INTRA-AMYGDALA ADMINISTRATION OF THE GABA-B AGONIST BACLOFEN IMPAIRS RETENTION
CASTELLANO, C
BRIONI, JD
NAGAHARA, AH
MCGAUGH, JL
BEHAVIORAL AND NEURAL BIOLOGY, 1989, 52 (02): : 170 - 179
[28] Effect of GABA-B receptor agonist SKF97541 on hippocampal epileptic afterdischarges
Fabera, P.
EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2010, 15 : 136 - 137
[29] The GABA-B receptor agonist Baclofen inhibits mechano-sensitive colon afferents in vitro and the visceromotor response to colorectal distension in vivo in rodents
Arvidsson, S
Phillis, BD
Brusberg, M
Kristensson, E
Kakol-Palm, D
Martinez, V
Larsson, H
Blackshaw, LA
Lindström, E
GASTROENTEROLOGY, 2005, 128 (04) : A222 - A223
[30] PREFRONTAL GABA-B RECEPTOR REGULATION OF GLUTAMATE RELEASE, LEARNING, AND ALCOHOL DRINKING
Melecio, L. M.
Melendez, R. I.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2016, 40 : 197A - 197A

← 1 2 3 4 5 →