The GABA-B receptor agonist baclofen helps patients with alcohol use disorder: why these findings matter

被引：7
作者：
Leggio, Lorenzo [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
Litten, Raye Z. [9 ]
机构：
[1] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, NIH, Baltimore, MD 21224 USA
[2] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, NIH, Bethesda, MD 20892 USA
[3] NIAAA, NIH, Baltimore, MD USA
[4] NIAAA, NIH, Bethesda, MD 20892 USA
[5] NIDA, Medicat Dev Program, Intramural Res Program, NIH, Baltimore, MD 21224 USA
[6] Brown Univ, Ctr Alcohol & Addict Studies, Dept Behav & Social Sci, Sch Publ Hlth, Providence, RI 02912 USA
[7] Johns Hopkins Univ, Sch Med, Dept Med, Div Addict Med, Baltimore, MD 21205 USA
[8] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA
[9] NIAAA, Div Treatment & Recovery, Bethesda, MD USA
来源：
NEUROPSYCHOPHARMACOLOGY | 2021年 / 46卷 / 13期
关键词：
DOUBLE-BLIND; SAFETY;
D O I：
10.1038/s41386-021-01142-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
[No abstract available]
引用
收藏
页码：2228 / 2229
页数：2
相关论文
共 9 条
  • [1] Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures
    Durant, Claire F.
    Paterson, Louise M.
    Turton, Sam
    Wilson, Susan J.
    Myers, James F. M.
    Muthukumaraswamy, Suresh
    Venkataraman, Ashwin
    Mick, Inge
    Paterson, Susan
    Jones, Tessa
    Nahar, Limon K.
    Cordero, Rosa E.
    Nutt, David J.
    Lingford-Hughes, Anne
    FRONTIERS IN PSYCHIATRY, 2018, 9
  • [2] Baclofen in the treatment of alcohol use disorder: tailored doses matter
    de Beaurepaire, Renaud
    Jaury, Philippe
    ALCOHOL AND ALCOHOLISM, 2024, 59 (02):
  • [3] Assessing Alcohol Versus Baclofen Withdrawal Syndrome in Patients Treated With Baclofen for Alcohol Use Disorder
    Rolland, Benjamin
    Jaillette, Emmanuelle
    Carton, Louise
    Bence, Camille
    Deheul, Sylvie
    Saulnier, Fabienne
    Bordet, Regis
    Cottencin, Olivier
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2014, 34 (01) : 153 - 156
  • [4] Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders
    Agabio, Roberta
    Leggio, Lorenzo
    FRONTIERS IN PSYCHIATRY, 2018, 9
  • [5] Baclofen for the Treatment of Alcohol Use Disorder in Patients With Liver Cirrhosis: 10 Years After the First Evidence
    Mosoni, Carolina
    Dionisi, Tommaso
    Vassallo, Gabriele Angelo
    Mirijello, Antonio
    Tarli, Claudia
    Antonelli, Mariangela
    Sestito, Luisa
    Rando, Maria Margherita
    Tosoni, Alberto
    De Cosmo, Salvatore
    Gasbarrini, Antonio
    Addolorato, Giovanni
    FRONTIERS IN PSYCHIATRY, 2018, 9
  • [6] Neurometabolite Levels in Alcohol Use Disorder Patients During Baclofen Treatment and Prediction of Relapse to Heavy Drinking
    Morley, Kirsten C.
    Lagopoulos, Jim
    Logge, Warren
    Chitty, Kate
    Baillie, Andrew
    Haber, Paul S.
    FRONTIERS IN PSYCHIATRY, 2018, 9
  • [7] A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic
    Owens, Lynn
    Thompson, Andrew
    Rose, Abi
    Gilmore, Ian
    Pirmohamed, Munir
    Richardson, Paul
    ALCOHOL, 2017, 62 : 11 - 15
  • [8] Systematic review and meta-analysis: Efficacy and safety of baclofen in patients with alcohol use disorder co-morbid liver diseases
    Duan, Fangfang
    Zhai, Hang
    Liu, Chen
    Chang, Chunyan
    Song, Shanshan
    Li, Junnan
    Cheng, Jun
    Yang, Song
    JOURNAL OF PSYCHIATRIC RESEARCH, 2023, 164 : 477 - 484
  • [9] The role of the D3 dopamine receptor and its partial agonist cariprazine in patients with schizophrenia and substance use disorder
    Grunze, Heinz
    EXPERT OPINION ON PHARMACOTHERAPY, 2023, 24 (18) : 1985 - 1992
1