The GABA-B receptor agonist baclofen helps patients with alcohol use disorder: why these findings matter

被引：7
|
作者：
Leggio, Lorenzo [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
Litten, Raye Z. [9 ]
机构：
[1] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, NIH, Baltimore, MD 21224 USA
[2] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, NIH, Bethesda, MD 20892 USA
[3] NIAAA, NIH, Baltimore, MD USA
[4] NIAAA, NIH, Bethesda, MD 20892 USA
[5] NIDA, Medicat Dev Program, Intramural Res Program, NIH, Baltimore, MD 21224 USA
[6] Brown Univ, Ctr Alcohol & Addict Studies, Dept Behav & Social Sci, Sch Publ Hlth, Providence, RI 02912 USA
[7] Johns Hopkins Univ, Sch Med, Dept Med, Div Addict Med, Baltimore, MD 21205 USA
[8] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA
[9] NIAAA, Div Treatment & Recovery, Bethesda, MD USA
来源：
NEUROPSYCHOPHARMACOLOGY | 2021年 / 46卷 / 13期
关键词：
DOUBLE-BLIND; SAFETY;
D O I：
10.1038/s41386-021-01142-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
[No abstract available]
引用
收藏
页码：2228 / 2229
页数：2
相关论文
共 50 条
  • [1] The GABA-B receptor agonist baclofen helps patients with alcohol use disorder: why these findings matter
    Lorenzo Leggio
    Raye Z. Litten
    Neuropsychopharmacology, 2021, 46 : 2228 - 2229
  • [2] Effects of a GABA-B receptor agonist baclofen on cortical epileptic afterdischarges in rats
    Mares, Pavel
    Lindovsky, Jiri
    Slamberova, Romana
    Kubova, Hana
    EPILEPTIC DISORDERS, 2007, 9 : S44 - S51
  • [3] REDUCTION OF GH RESPONSE TO THE GABA-B AGONIST BACLOFEN IN PATIENTS WITH MAJOR DEPRESSION
    MARCHESI, C
    CHIODERA, P
    DEFERRI, A
    DERISIO, C
    DASSO, L
    MENOZZI, P
    VOLPI, R
    COIRO, V
    PSYCHONEUROENDOCRINOLOGY, 1991, 16 (06) : 475 - 479
  • [4] DOES CENTRAL ADMINISTRATION OF THE GABA-B RECEPTOR AGONIST BACLOFEN PRODUCE HYPERPHAGIA IN RATS
    EBENEZER, IS
    BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 : P570 - P570
  • [5] Anticonvulsant Action of GABA-B Receptor Agonist SKF97541 Differs from That of Baclofen
    Mares, P.
    PHYSIOLOGICAL RESEARCH, 2008, 57 (05) : 789 - 792
  • [6] Baclofen, a GABA-B Agonist, Improves Alcohol Consumption, Psychometrics and Hospital Admission Rates in Patients with Alcoholic Liver Disease
    Macdonald, Benn
    Masson, Neil
    Lewsey, Jim
    Cunningham, Leona
    Irnazarow, Aleksandra
    Nardone, Amanda
    Cosgrave, Jan
    Chick, Jonathan
    Heydtmann, Mathis
    SCOTTISH MEDICAL JOURNAL, 2013, 58 (01) : E51 - E52
  • [7] MODULATION OF PULSATILE LH-SECRETION BY BACLOFEN, A SELECTIVE GABA-B RECEPTOR AGONIST, IN OVARIECTOMIZED RATS
    AKEMA, T
    KIMURA, F
    NEUROENDOCRINOLOGY, 1992, 56 (02) : 141 - 147
  • [8] Effect of the GABA-B agonist baclofen on proximal gastric motor function in normal subjects
    Zhang, Q
    Noomen, G
    Wu, J
    Rigda, R
    Holloway, RH
    GASTROENTEROLOGY, 2001, 120 (05) : A463 - A463
  • [9] The GABA-B agonist Baclofen Improves Alcohol Consumption, psychometrics and May Have an Effect on Hospital Admission Rates in Patients with Alcoholic Liver disease
    Heydtmann, Mathis
    Macdonald, Benn
    Lewsey, Jim
    Masson, Neil
    Cunningham, Leona
    Irnazarow, Aleksandra M.
    Nardone, Amanda
    Cosgrave, Jan
    Chick, Jonathan
    HEPATOLOGY, 2012, 56 : 1091A - 1091A
  • [10] Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures
    Durant, Claire F.
    Paterson, Louise M.
    Turton, Sam
    Wilson, Susan J.
    Myers, James F. M.
    Muthukumaraswamy, Suresh
    Venkataraman, Ashwin
    Mick, Inge
    Paterson, Susan
    Jones, Tessa
    Nahar, Limon K.
    Cordero, Rosa E.
    Nutt, David J.
    Lingford-Hughes, Anne
    FRONTIERS IN PSYCHIATRY, 2018, 9
12345