Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation

被引：171

作者：

Mick, David U. ^{[1
]}

Fox, Thomas D. ^{[2
]}

Rehling, Peter ^{[1
,3
]}

机构：

[1] Univ Gottingen, Biochem Abt 2, D-37073 Gottingen, Germany

[2] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

[3] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 01期

关键词：

SACCHAROMYCES-CEREVISIAE MITOCHONDRIA; RESPIRATORY-CHAIN COMPLEXES; MESSENGER-RNA; LEIGH-SYNDROME; RIBOSOME-BINDING; GENE-EXPRESSION; INNER-MEMBRANE; YEAST; PROTEIN; COX1;

D O I：

10.1038/nrm3029

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with imported subunits that are encoded in the nucleus. New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex.

引用

页码：14 / 20

页数：8

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