Chiral [RuCl2(dipyridylphosphane)(1,2-diamine)] catalysts:: Applications in asymmetric hydrogenation of a wide range of simple ketones

被引：115

作者：

Wu, J ^{[1
]}

Ji, JX ^{[1
]}

Guo, RW ^{[1
]}

Yeung, CH ^{[1
]}

Chan, ASC ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2003年 / 9卷 / 13期

关键词：

asymmetric catalysis; enantioselectivity; hydrogentation; P ligands; ruthenium;

D O I：

10.1002/chem.200204688

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dipyridylphosphane/diamine-Ru complex combined with tBuOK in 2-propanol acts as a very effective catalyst system for the enantioselective hydrogenation of a diverse range of simple ketones including heteroaromatic ketones, substituted benzophenones, alkenyl ketones, and cyclopropyl ketones. The combination of desirable features, such as quantitative chemical yields within hours, broad substrate scope, excellent enantioselectivities (up to 99%) and high substrate-to-catalyst ratios, among others, makes the present catalyst system of high practical interest.

引用

页码：2963 / 2968

页数：6

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