Domino [3+1+1] heterocyclization providing an efficient umpolung strategy for synthesis of 2-(2'-azaaryl)imidazoles

被引：2

作者：

Zhang, Xiao-Jing ^{[1
]}

Fan, Wei ^{[2
,3
]}

Fu, Li-Ping ^{[2
,3
]}

Jiang, Bo ^{[2
,3
]}

Tu, Shu-Jiang ^{[2
,3
]}

机构：

[1] Yunhe Teachers Coll, Xuzhou 221300, Jiangsu, Peoples R China

[2] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 211116, Peoples R China

[3] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 211116, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 02期

基金：

美国国家科学基金会;

关键词：

Heterocyclization; Microwave irradiation; Umpolung process; Multicomponent reactions; 2-(2-PYRIDYL)IMIDAZOLE; CARBENES; DESIGN;

D O I：

10.1007/s11164-013-1227-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Concise and efficient three-component domino [3+1+1] heterocyclization to highly substituted 2-(2'-azaaryl)imidazoles, promoted by K2CO3 under microwave irradiation conditions, has been developed. The reactions have broad substrate scope which includes a wide range of common commercially available aromatic aldehydes and heteroaryl-amidines. A mechanism involving the umpolung process has been proposed for formation of the 2-(2'-azaaryl)imidazoles.

引用

页码：773 / 783

页数：11

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