Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09

被引:6
作者
Flores-Torres, Armando S. [1 ]
Rendon, Adrian [2 ]
Salinas-Carmona, Mario C. [1 ]
Salinas, Eva [3 ]
Rosas-Taraco, Adrian G. [1 ]
机构
[1] Univ Autonoma Nuevo Leon, Fac Med, Dept Immunol, Gonzalitos 235 Norte, Monterrey 66460, Nuevo Leon, Mexico
[2] Univ Autonoma Nuevo Leon Monterrey, Univ Hosp, Ctr Res Prevent & Treatment Resp Dis CIPTIR, San Nicolas De Los Garza, Nuevo Leon, Mexico
[3] Univ Autonoma Aguascalientes, Ctr Basic Sci, Dept Microbiol, Aguascalientes, Aguascalientes, Mexico
关键词
eosinophil; influenza virus; sialic acid; RIG-I; IL-8; HOST-DEFENSE; ACTIVATION; RECEPTORS; INFLAMMATION; CYTOKINES; IMMUNITY; ALLERGY;
D O I
10.1089/vim.2021.0004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Eosinophils participate in the immune response against many pathogens, including viruses. Since mouse eosinophils are susceptible to influenza A virus infection and possess antiviral activity, we evaluated the expression of sialic acid residues in human eosinophils and their response against influenza virus in vitro. We demonstrated that human eosinophils express alpha 2,6- and alpha 2,3-linked sialic acid, and drastically reduced influenza virus titer. After influenza virus exposure, eosinophils upregulated retinoic acid-inducible gene I (RIG-I) mRNA expression, but no other pattern recognition receptors. Finally, high concentrations of interleukin-8 (IL-8) were found in influenza virus-exposed eosinophil cultures. These data suggest that human eosinophils possess antiviral activity and may play a role in the innate immune response to influenza virus.
引用
收藏
页码:573 / 578
页数:6
相关论文
共 40 条
[1]   Eosinophilic Endotype of Asthma [J].
Aleman, Fernando ;
Lim, Hui Fang ;
Nair, Parameswaran .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2016, 36 (03) :559-+
[2]  
[Anonymous], 2016, INFL SEAS FACT SHEET
[3]  
[Anonymous], 2018, INFL AV OTH ZOON FAC
[4]   In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus [J].
Benitez, Asiel A. ;
Panis, Maryline ;
Xue, Jia ;
Varble, Andrew ;
Shim, Jaehee V. ;
Frick, Amy L. ;
Lopez, Carolina B. ;
Sachs, David ;
tenOever, Benjamin R. .
CELL REPORTS, 2015, 11 (11) :1714-1726
[5]   Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity [J].
Davoine, Francis ;
Lacy, Paige .
FRONTIERS IN IMMUNOLOGY, 2014, 5
[6]   Effects of three IL-15 variants on NCI-H446 cell proliferation and expression of cell cycle regulatory molecules [J].
Ding, Jun-Ying ;
Wang, Zhi-Hua ;
Zhang, Zheng-Zheng ;
Cui, Xu-Ran ;
Hong, Yan-Ying ;
Liu, Qing-Quan .
ONCOTARGET, 2017, 8 (64) :108108-108117
[7]   Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus [J].
Drake, Matthew G. ;
Bivins-Smith, Elizabeth R. ;
Proskocil, Becky J. ;
Nie, Zhenying ;
Scott, Gregory D. ;
Lee, James J. ;
Lee, Nancy A. ;
Fryer, Allison D. ;
Jacoby, David B. .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2016, 55 (03) :387-394
[8]   Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6 [J].
Dyer, Kimberly D. ;
Percopo, Caroline M. ;
Fischer, Elizabeth R. ;
Gabryszewski, Stanislaw J. ;
Rosenberg, Helene F. .
BLOOD, 2009, 114 (13) :2649-2656
[9]   Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness [J].
Edwards, Michael R. ;
Strong, Katherine ;
Cameron, Aoife ;
Walton, Ross P. ;
Jackson, David J. ;
Johnston, Sebastian L. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (04) :909-920
[10]   Eosinophils and Respiratory Viruses [J].
Flores-Torres, Armando S. ;
Salinas-Carmona, Mario C. ;
Salinas, Eva ;
Rosas-Taraco, Adrian G. .
VIRAL IMMUNOLOGY, 2019, 32 (05) :198-207