Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09

被引：6

作者：

Flores-Torres, Armando S. ^{[1
]}

Rendon, Adrian ^{[2
]}

Salinas-Carmona, Mario C. ^{[1
]}

Salinas, Eva ^{[3
]}

Rosas-Taraco, Adrian G. ^{[1
]}

机构：

[1] Univ Autonoma Nuevo Leon, Fac Med, Dept Immunol, Gonzalitos 235 Norte, Monterrey 66460, Nuevo Leon, Mexico

[2] Univ Autonoma Nuevo Leon Monterrey, Univ Hosp, Ctr Res Prevent & Treatment Resp Dis CIPTIR, San Nicolas De Los Garza, Nuevo Leon, Mexico

[3] Univ Autonoma Aguascalientes, Ctr Basic Sci, Dept Microbiol, Aguascalientes, Aguascalientes, Mexico

来源：

VIRAL IMMUNOLOGY | 2021年 / 34卷 / 08期

关键词：

eosinophil; influenza virus; sialic acid; RIG-I; IL-8; HOST-DEFENSE; ACTIVATION; RECEPTORS; INFLAMMATION; CYTOKINES; IMMUNITY; ALLERGY;

D O I：

10.1089/vim.2021.0004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eosinophils participate in the immune response against many pathogens, including viruses. Since mouse eosinophils are susceptible to influenza A virus infection and possess antiviral activity, we evaluated the expression of sialic acid residues in human eosinophils and their response against influenza virus in vitro. We demonstrated that human eosinophils express alpha 2,6- and alpha 2,3-linked sialic acid, and drastically reduced influenza virus titer. After influenza virus exposure, eosinophils upregulated retinoic acid-inducible gene I (RIG-I) mRNA expression, but no other pattern recognition receptors. Finally, high concentrations of interleukin-8 (IL-8) were found in influenza virus-exposed eosinophil cultures. These data suggest that human eosinophils possess antiviral activity and may play a role in the innate immune response to influenza virus.

引用

页码：573 / 578

页数：6

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