Pancreatic Lipase Inhibitory Activity of Citrus unshiu Leaf Extract

被引：8

作者：

Itoh, Kimihisa ^{[1
]}

Matsukawa, Tetsuya ^{[1
,2
]}

Murata, Kazuya ^{[3
]}

Nishitani, Ryota ^{[3
]}

Yamagami, Momona ^{[3
]}

Tomohiro, Norimichi ^{[1
]}

Kajiyama, Shin'ichiro ^{[2
]}

Fumuro, Masahiko ^{[1
]}

Iijima, Morio ^{[4
]}

Shigeoka, Shigeru ^{[1
]}

Endo, Yuichi ^{[3
]}

Matsuda, Hideaki ^{[1
,3
]}

机构：

[1] Kindai Univ, Expt Farm, 2355-2 Yuasa, Yuasa, Wakayama 6430004, Japan

[2] Kindai Univ, Fac Biol Oriented Sci & Technol, Wakayama, Japan

[3] Kindai Univ, Fac Pharm, Osaka, Japan

[4] Kindai Univ, Fac Agr, Nara, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 09期

关键词：

lipase inhibitory activity; Citrus unshiu; leaves; nobiletin; rutin; hesperidin; LIQUID-CHROMATOGRAPHY; AERIAL PARTS; IDENTIFICATION; L;

D O I：

10.1177/1934578X19873439

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the cultivation of Citrus fruit, pruning in late winter after harvest is important to obtain excellent flower buds in the next spring and a rich harvest of superior fruit in the following winter; a large number of pruned leaves are usually discarded. The purpose of this study was to determine the utility value of pruned leaves of Citrus unshiu. A methanol extract of pruned C. unshiu leaves showed a porcine pancreatic lipase inhibitory activity. Fractionation of C. unshiu leaf extract (CUL-ext) followed by bibliographic and chromatographic analyses revealed that a part of the pancreatic lipase inhibitory activity of CUL-ext was attributable to nobiletin (1), rutin (2), and hesperidin (3). Thus, pruned C. unshiu leaves may be a reasonable natural resource for the preparation of ingredients with lipase inhibitory activity.

引用

页数：5

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