Heme oxygenase enzyme activity in seminal plasma of oligoasthenoteratozoospermic males with varicocele

被引：24
作者：
Aziz, M. T. Abdel [2 ]
Mostafa, T. [1 ]
Atta, H. [2 ]
Kamal, O. [1 ]
Kamel, M. [2 ]
Hosni, H. [2 ]
Rashed, L. [2 ]
Sabry, D. [2 ]
Waheed, F. [1 ]
机构：
[1] Cairo Univ, Fac Med, Dept Androl & Sexol, Cairo 11562, Egypt
[2] Cairo Univ, Fac Med, Mol Biol Unit, Dept Med Biochem, Cairo, Egypt
来源：
ANDROLOGIA | 2010年 / 42卷 / 04期
关键词：
Heme oxygenase enzyme; male infertility; semen; seminal plasma; varicocele; OXIDATIVE STRESS; CARBON-MONOXIDE; SPERMATIC VEIN; INFERTILE MEN; TESTICULAR DYSFUNCTION; RAT TESTIS; FERTILE; SYSTEM; PROTEIN; EXPRESSION;
D O I：
10.1111/j.1439-0272.2009.00983.x
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
P>This work aimed to assess seminal plasma heme oxygenase (HO) enzyme activity in oligoasthenoteratozoospermia (OAT) males with varicocele. Ninety-three men were divided according to their sperm count and clinical examination into: healthy fertile controls (n = 34), OAT without varicocele (n = 37) and OAT associated with varicocele (n = 22). They were subjected to semen analysis and estimation of seminal plasma HO enzyme activity in the form of bilirubin concentration. Seminal plasma HO enzyme activity decreased significantly in OAT cases compared with controls. Seminal plasma HO in OAT cases associated with varicocele decreased significantly compared with OAT cases without varicocele and healthy controls (mean +/- SD; 109.2 +/- 29.5, 283.6 +/- 88.4, 669.5 +/- 236.1 nMol bilirubin/mg ptn/min, P < 0.001). There was positive correlation between seminal plasma HO enzyme activity and sperm concentration, per cent of motile spermatozoa, number of motile spermatozoas ml-1 and significant negative correlation with sperm abnormal forms per cent. It is concluded that varicocele has a negative impact on seminal HO enzyme activity. Therefore, improved seminal picture after correcting varicocele repair might be related, in part, to improved HO action(s).
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页码：236 / 241
页数：6
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