Regenerative Chemical Biology: Current Challenges and Future Potential

被引：21
作者：
Ao, Ada [1 ]
Hao, Jijun [1 ]
Hong, Charles C. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Vanderbilt Univ, Sch Med, Dept Med, Div Cardiovasc Med, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN 37232 USA
[4] Vanderbilt Univ, Sch Med, Vanderbilt Inst Chem Biol, Nashville, TN 37232 USA
[5] Vet Affairs TVHS, Nashville, TN 37212 USA
来源：
CHEMISTRY & BIOLOGY | 2011年 / 18卷 / 04期
关键词：
EMBRYONIC STEM-CELLS; LINEAGE-COMMITTED CELLS; SMALL-MOLECULE; SELF-RENEWAL; MOUSE EPIBLAST; NEURONAL DIFFERENTIATION; SOMATIC-CELLS; SERUM-FREE; PLURIPOTENCY; GENERATION;
D O I：
10.1016/j.chembiol.2011.03.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The enthusiasm surrounding the clinical potential of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is tempered by the fact that key issues regarding their safety, efficacy, and long-term benefits have thus far been suboptimal. Small molecules can potentially relieve these problems at major junctions of stem cell biology and regenerative therapy. In this review we will introduce recent advances in these important areas and the first generation of small molecules used in the regenerative context. Current chemical biology studies will provide the archetype for future interdisciplinary collaborations and improve clinical benefits of cell-based therapies.
引用
收藏
页码：413 / 424
页数：12
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