MyMpn: a database for the systems biology model organism Mycoplasma pneumoniae

被引:22
作者
Wodke, Judith A. H. [1 ,2 ,3 ]
Alibes, Andreu [2 ,4 ]
Cozzuto, Luca [2 ,4 ]
Hermoso, Antonio [2 ,4 ]
Yus, Eva [1 ,2 ]
Lluch-Senar, Maria [1 ,2 ]
Serrano, Luis [1 ,2 ,5 ]
Roma, Guglielmo [2 ,4 ]
机构
[1] Ctr Genom Regulat, EMBL CRG Syst Biol Res Unit, Barcelona 08003, Spain
[2] Univ Pompeu Fabra, Barcelona 08003, Spain
[3] Humboldt Univ, D-10115 Berlin, Germany
[4] Ctr Genom Regulat CRG, CRG Bioinformat Facil, Barcelona 08003, Spain
[5] Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Spain
基金
欧洲研究理事会;
关键词
GENOME-REDUCED BACTERIUM; METABOLISM; PROTEIN; INFORMATION; INTEGRATION; RESOURCE; SEQUENCE; GROWTH; PPLO; RNA;
D O I
10.1093/nar/gku1105
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
MyMpn ( ext-link-type="uri" xlink:href="http://mympn.crg.eu" xlink:type="simple">http://mympn.crg.eu) is an online resource devoted to studying the human pathogen Mycoplasma pneumoniae, a minimal bacterium causing lower respiratory tract infections. Due to its small size, its ability to grow in vitro, and the amount of data produced over the past decades, M. pneumoniae is an interesting model organisms for the development of systems biology approaches for unicellular organisms. Our database hosts a wealth of omics-scale datasets generated by hundreds of experimental and computational analyses. These include data obtained from gene expression profiling experiments, gene essentiality studies, protein abundance profiling, protein complex analysis, metabolic reactions and network modeling, cell growth experiments, comparative genomics and 3D tomography. In addition, the intuitive web interface provides access to several visualization and analysis tools as well as to different data search options. The availability and-even more relevant-the accessibility of properly structured and organized data are of up-most importance when aiming to understand the biology of an organism on a global scale. Therefore, MyMpn constitutes a unique and valuable new resource for the large systems biology and microbiology community.
引用
收藏
页码:D618 / D623
页数:6
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