The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

被引：115
作者：
Baxendale, IR
Ley, SV
Martinelli, M
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] NiKem Res Srl, Milan, Italy
来源：
TETRAHEDRON | 2005年 / 61卷 / 22期
基金：
英国工程与自然科学研究理事会;
关键词：
polymer-supported reagents; oxaziazole; thiadiazole; combinatorial chemistry; microwave;
D O I：
10.1016/j.tet.2005.03.062
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-ammosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5323 / 5349
页数：27
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