Vaccination of poultry successfully eliminated human infection with H7N9 virus in China

被引：135

作者：

Zeng, Xianying ^{[1
]}

Tian, Guobin ^{[1
]}

Shi, Jianzhong ^{[1
]}

Deng, Guohua ^{[1
]}

Li, Chengjun ^{[1
]}

Chen, Hualan ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150069, Heilongjiang, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2018年 / 61卷 / 12期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

H7N9 influenza virus; evolution; vaccination; human infection; elimination; H5N1 AVIAN INFLUENZA; LIVE ATTENUATED VACCINE; PROTECTIVE EFFICACY; A VIRUSES; AIRBORNE TRANSMISSION; DOMESTIC POULTRY; RECEPTOR-BINDING; MOLECULAR-BASIS; CHICKENS; FERRETS;

D O I：

10.1007/s11427-018-9420-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The H7N9 viruses that emerged in China in 2013 were nonpathogenic in chickens but mutated to a highly pathogenic form in early 2017 and caused severe disease outbreaks in chickens. The H7N9 influenza viruses have caused five waves of human infection, with almost half of the total number of human cases (766 of 1,567) being reported in the fifth wave, raising concerns that even more human infections could occur in the sixth wave. In September 2017, an H5/H7 bivalent inactivated vaccine for chickens was introduced, and the H7N9 virus isolation rate in poultry dropped by 93.3% after vaccination. More importantly, only three H7N9 human cases were reported between October 1, 2017 and September 30, 2018, indicating that vaccination of poultry successfully eliminated human infection with H7N9 virus. These facts emphasize that active control of animal disease is extremely important for zoonosis control and human health protection.

引用

页码：1465 / 1473

页数：9

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