Regulation of Appetite, Satiation, and Body Weight by Enteroendocrine Cells. Part 2: Therapeutic Potential of Enteroendocrine Cells in the Treatment of Obesity

被引：13

作者：

Posovszky, Carsten ^{[1
]}

Wabitsch, Martin ^{[2
]}

机构：

[1] Univ Med Ctr Ulm, Dept Pediat & Adolescent Med, Univ Outpatient Clin Pediat Gastroenterol, DE-89075 Ulm, Germany

[2] Univ Med Ctr Ulm, Dept Pediat & Adolescent Med, Div Pediat Endocrinol & Diabet, DE-89075 Ulm, Germany

来源：

HORMONE RESEARCH IN PAEDIATRICS | 2015年 / 83卷 / 01期

关键词：

Enteroendocrine cells; Satiation; Appetite; Obesity; Taste receptors; GLUCAGON-LIKE PEPTIDE-1; GASTRIC BYPASS-SURGERY; BARIATRIC SURGERY; GUT MICROBIOTA; CHILDHOOD OBESITY; CHILDREN; HORMONES; SATIETY; INSULIN; GLUCOSE;

D O I：

10.1159/000369555

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is an epidemic and medical issue. Investigating the pathways regulating appetite, food intake, and body weight is crucial to find strategies for the prevention and treatment of obesity. In the context of therapeutic strategies, we focus here on the potential of enteroendocrine cells (EECs) and their secreted hormones in the regulation of body weight. We review the role of the enteroendocrine system during weight loss after lifestyle intervention or after bariatric surgery. We discuss the therapeutic potential of EECs and their hormones as targets for new treatment strategies. In fact, targeting nutrient receptors of EECs with a nutritional approach, pharmaceutical agents or prebiotics delivered to the lumen may provide a promising new approach. (C) 2015 S. Karger AG, Basel

引用

页码：11 / 18

页数：8

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