Synthesis of Polysubstituted Olefins by Pd-Catalyzed Cross-Coupling Reaction of Tosylhydrazones and Aryl Nonaflates

被引：118

作者：

Barluenga, Jose ^{[1
]}

Florentino, Lucia ^{[1
]}

Aznar, Fernando ^{[1
]}

Valdes, Carlos ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organometal Enrique Moles, E-33006 Oviedo, Spain

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 03期

关键词：

SERTRALINE; TOSYLATES; HALIDES; METAL;

D O I：

10.1021/ol102884g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aryl nonaflates are employed as electrophiles in the Pd-catalyzed cross-coupling with tosylhydrazones affording di-, tri-, and tetrasubstituted olefins. Fine tunning of the reaction conditions are required to accomplish the coupling successfully, including the addition of LICI and the presence of small amounts of water. Under the optimized conditions, the reactions proceed with high yield and also high stereoselectivity depending on the nature of the coupling partners.

引用

页码：510 / 513

页数：4

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