Thermo- and pH-responsive biodegradable poly(α-N-substituted γ-glutamine)s

被引：59
|
作者：
Tachibana, Y [1 ]
Kurisawa, M [1 ]
Uyama, H [1 ]
Kobayashi, S [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Mat, Kyoto 6158510, Japan
来源：
BIOMACROMOLECULES | 2003年 / 4卷 / 05期
关键词：
D O I：
10.1021/bm034123y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New double stimuli-responsive poly(alpha-N-substituted gamma-glutamine) has been developed, which was synthesized by the reaction of poly(gamma-glutamic acid) with amino alcohols. Appropriate combinations of the amino alcohols provided the biodegradable poly(amino acid) exhibiting a sharp lower critical solution temperature (LCST) in water. Furthermore, the phase transition temperature was highly sensitive to pH changes.
引用
收藏
页码：1132 / 1134
页数：3
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