Impact of Cyclooxygenase-2 1195 G-Carrier Genotype Associated with Intestinal Metaplasia and Endoscopic Findings Based on Kyoto Classification

被引：5

作者：

Kodaka, Yasuhiro ^{[1
]}

Futagami, Seiji ^{[1
]}

Tatsuguchi, Atsushi ^{[1
]}

Yamawaki, Hiroshi ^{[1
]}

Sato, Hitomi ^{[1
]}

Hashimoto, Satomi ^{[1
]}

Kawagoe, Tetsuro ^{[1
]}

Ueki, Nobue ^{[1
]}

Nagoya, Hiroyuki ^{[1
]}

Maruki, Yuuta ^{[1
]}

Miyake, Kazumasa ^{[1
]}

Gudis, Katya ^{[1
]}

Sakamoto, Choitsu ^{[1
]}

Iwakiri, Katsuhiko ^{[1
]}

机构：

[1] Nippon Med Sch, Div Gastroenterol, Dept Internal Med, Tokyo, Japan

来源：

DIGESTION | 2017年 / 96卷 / 03期

关键词：

Cyclooxygenase-2; Microsomal prostaglandin E synthase-1; Polymorphism; Endoscopic findings; H; pylori; Intestinal metaplasia; Kyoto classification; PROSTAGLANDIN-E SYNTHASE-1; HELICOBACTER-PYLORI INFECTION; GASTRIC-CANCER; GENETIC-VARIANTS; TRANSGENIC MICE; E-2; SYNTHASE; EXPRESSION; RISK; CELLS; IDENTIFICATION;

D O I：

10.1159/000479864

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: We aimed to clarify whether cyclooxygenase- 2 (COX-2) and microsomal prostaglandin E synthase- 1 (mPGES-1) genotypes were associated with certain histological findings and endoscopical appearances based on Kyoto classification. Methods: We enrolled 285 Helicobacter pylori -infected gastritis patients. Genotypes of COX-2 1195, COX-2 1290, mPGES-1, interleukin-1 beta (IL-1 beta) 511 and tumour necrosis factor-alpha (TNF-alpha) 308 were analyzed. Genotyping was performed by polymerase chain reaction. Endoscopic appearances and histological assessment were determined by using Kyoto classification, operative link on gastritic intestinal metaplasia assessment and the updated Sydney system. Results: There was a significant (p = 0.027) relationship between the IL-1 beta 511 C-carrier and histological gastric inflammation in H. pylori -infected gastritis patients. There was a significant (p = 0.009) correlation between the COX-2 1195 G-carrier genotype and histological intestinal metaplasia in the gastric antrum of H. pylori -infected gastritis patients and gastric xanthoma (p = 0.027). The COX-2 1195 G-carrier genotype was also significantly (p = 0.038) associated with the score of endoscopic intestinal metaplasia based on Kyoto classification. The mPGES-1 genotype was significantly (p = 0.002) associated with endoscopic swelling of area. Conclusion: Our results suggest that in Japan, there exists a significant correlation between the COX-2 1195 Gcarrier genotype and intestinal metaplasia in histological and endoscopic findings based on Kyoto classification in H. pylori -infected gastric mucosa. (C) 2017 S. Karger AG, Basel

引用

页码：173 / 183

页数：11