The role of 5-HT metabolism in cancer

被引：31
|
作者：
Ye, Di
Xu, Huanji
Tang, Qiulin
Xia, Hongwei
Zhang, Chenliang
Bi, Feng [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Canc Ctr, Dept Med Oncol, Chengdu 610041, Sichuan, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1876卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Serotonin; Metabolism; Cancer therapy; MONOAMINE-OXIDASE; COLORECTAL-CANCER; TELOTRISTAT ETHYL; SEROTONIN RECEPTORS; NEUROENDOCRINE TUMOR; PERIPHERAL SEROTONIN; MOUSE MODEL; EXPRESSION; CELLS; ANGIOGENESIS;
D O I：
10.1016/j.bbcan.2021.188618
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Serotonin (5-hydroxytryptamine, 5-HT) metabolism has long been linked to tumorigenesis and tumor progression. Numerous studies have shown the functions of 5-HT and its metabolites in the regulation of tumor biological processes like cell proliferation, invasion, metastasis, tumor angiogenesis and immunomodulatory through multi-step complex mechanisms. Reprogramming of 5-HT metabolism has been revealed in various tumors paving way for development of drugs that target enzymes, metabolites or receptors involved in 5-HT metabolic pathway. However, information on the role of 5-HT metabolism in cancer is scanty. This review briefly describes the main metabolic routes of 5-HT, the role of 5-HT metabolism in cancer and systematically summarizes the most recent advances in 5-HT metabolism-targeted cancer therapy.
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页数：8
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