Analysis of skin tissues spatial fluorescence distribution by the Monte Carlo simulation

被引:52
作者
Churmakov, DY [1 ]
Meglinski, IV
Piletsky, SA
Greenhalgh, DA
机构
[1] Cranfield Univ, Sch Engn, Cranfield MK43 0AL, Beds, England
[2] Cranfield Univ, Inst Biosci & Technol, Silsoe MK45 4DT, England
关键词
D O I
10.1088/0022-3727/36/14/311
中图分类号
O59 [应用物理学];
学科分类号
摘要
A novel Monte Carlo technique of simulation of spatial fluorescence distribution within the human skin is presented. The computational model of skin takes into account the spatial distribution of fluorophores, which would arise due to the structure of collagen fibres, compared to the epidermis and stratum corneum where the distribution of fluorophores is assumed to be homogeneous. The results of simulation suggest that distribution of auto-fluorescence is significantly suppressed in the near-infrared spectral region, whereas the spatial distribution of fluorescence sources within a sensor layer embedded in the epidermis is localized at an 'effective' depth.
引用
收藏
页码:1722 / 1728
页数:7
相关论文
共 44 条
[1]   Quantitative optical biopsy of liver tissue ex vivo [J].
Beuthan, J ;
Minet, O ;
Muller, G .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 1996, 2 (04) :906-913
[2]   Ultraviolet and visible spectroscopies for tissue diagnostics: Fluorescence spectroscopy and elastic-scattering spectroscopy [J].
Bigio, IJ ;
Mourant, JR .
PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (05) :803-814
[3]   Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head [J].
Boas, DA ;
Culver, JP ;
Stott, JJ ;
Dunn, AK .
OPTICS EXPRESS, 2002, 10 (03) :159-170
[4]   Imaging the body with diffuse optical tomography [J].
Boas, DA ;
Brooks, DH ;
Miller, EL ;
DiMarzio, CA ;
Kilmer, M ;
Gaudette, RJ ;
Zhang, Q .
IEEE SIGNAL PROCESSING MAGAZINE, 2001, 18 (06) :57-75
[5]   Influence of refractive index matching on the photon diffuse reflectance [J].
Churmakov, DY ;
Meglinski, IV ;
Greenhalgh, DA .
PHYSICS IN MEDICINE AND BIOLOGY, 2002, 47 (23) :4271-4285
[6]   Forward-adjoint fluorescence model: Monte Carlo integration and experimental validation [J].
Crilly, RJ ;
Cheong, WF ;
Wilson, B ;
Spears, JR .
APPLIED OPTICS, 1997, 36 (25) :6513-6519
[7]   The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy [J].
Doornbos, RMP ;
Lang, R ;
Aalders, MC ;
Cross, FW ;
Sterenborg, HJCM .
PHYSICS IN MEDICINE AND BIOLOGY, 1999, 44 (04) :967-981
[8]   RELATION BETWEEN FLUORESCENCE-SPECTRA OF DILUTE AND TURBID SAMPLES [J].
DURKIN, AJ ;
JAIKUMAR, S ;
RAMANUJAM, N ;
RICHARDSKORTUM, R .
APPLIED OPTICS, 1994, 33 (03) :414-423
[9]   Effects of multiple-passage probabilities on fluorescent signals from biological media [J].
Gandjbakhche, AH ;
Bonner, RF ;
Nossal, R ;
Weiss, GH .
APPLIED OPTICS, 1997, 36 (19) :4613-4619
[10]   CONDENSED MONTE-CARLO SIMULATIONS FOR THE DESCRIPTION OF LIGHT TRANSPORT [J].
GRAAFF, R ;
KOELINK, MH ;
DEMUL, FFM ;
ZIJLSTRA, WG ;
DASSEL, ACM ;
AARNOUDSE, JG .
APPLIED OPTICS, 1993, 32 (04) :426-434