Which oxidant is really responsible for sulfur oxidation by cytochrome p450?

被引：66

作者：

Li, Chunsen ^{[1
,2
]}

Zhang, Lixian ^{[1
,2
]}

Zhang, Chi ^{[1
,2
]}

Hirao, Hajime ^{[1
,2
]}

Wu, Wei ^{[1
,2
]}

Shaik, Sason ^{[1
,2
]}

机构：

[1] Xiamen Univ, Ctr Theoret Chem, Dept Chem, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[2] Hebrew Univ Jerusalem, Lise Meitner Minerva Ctr Computat Quantum Chem, Dept Organ Chem, IL-91904 Jerusalem, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 43期

关键词：

D O I：

10.1002/anie.200702867

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Clarifying a conundrum: The question of whether Compound I or Compound 0 (Cpd I or Cpd 0) is the reactive oxidant in the sulfoxidation of thiafatty acids by P450 is addressed by theory, which demonstrates that Cpd I leads to an extremely fast process, while Cpd 0 is at least six orders of magnitude slower. Most likely, thiafatty acids promote Cpd I formation even in the T→A mutant of P450BM3. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8168 / 8170

页数：3

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