Familial Hemiplegic Migraine: Probable linkage to chromosome 1 and genetic heterogeneity

被引：0

作者：

Cevoli, S ^{[1
]}

Monari, L ^{[1
]}

Valentino, ML ^{[1
]}

Pierangeli, G ^{[1
]}

Bernardoni, P ^{[1
]}

Granella, F ^{[1
]}

Soriani, S ^{[1
]}

Mochi, M ^{[1
]}

Certelli, P ^{[1
]}

Montagna, P ^{[1
]}

机构：

[1] Univ Bologna, Ist Clin Neurol, I-40123 Bologna, Italy

来源：

CONFINIA CEPHALALGICA | 2000年 / 9卷 / 03期

关键词：

Familial Emiplegic Migraine; genetics; linkage analysis;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Familial hemiplegic migraine (FHM) is an autosomal dominant form of migraine with aura. FHM is genetically heterogeneous. In about 50 % of families FHM is ca used by mutations in the CACNA1A gene on chromosome 19. Linkage to 1q31 e 1q21-23 has also been established. We observed two Italian families both unlinked to chromosome 19. In one family with probable linkage to chromosome 1q21-23, some affected members showed cerebellar signs, previously reported only in families linked to chromosome 19. Our families confirms the genetic heterogeneity of FHM.

引用

页码：117 / 121

页数：5

共 6 条

[1]

BLAU JN, 1955, LANCET, V2, P1115

[2] Mapping of a second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity [J].

Ducros, A ;

Joutel, A ;

Vahedi, K ;

Cecillon, M ;

Ferreira, A ;

Bernard, E ;

Verier, A ;

Echenne, B ;

de Munain, AL ;

Bousser, MG ;

Tournier-Lasserve, E .

ANNALS OF NEUROLOGY, 1997, 42 (06) :885-890

[3] A new locus for hemiplegic migraine maps to chromosome 1q31 [J].

Gardner, K ;

Barmada, MM ;

Ptacek, LJ ;

Hoffman, EP .

NEUROLOGY, 1997, 49 (05) :1231-1238

[4]

*INT HEAD SOC HEAD, 1988, CEPHALALGIA S7, V8, P19, DOI DOI 10.1111/J.1468-2982.1991.TB00022.X

[5] Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4 [J].

Ophoff, RA ;

Terwindt, GM ;

Vergouwe, MN ;

vanEijk, R ;

Oefner, PJ ;

Hoffman, SMG ;

Lamerdin, JE ;

Mohrenweiser, HW ;

Bulman, DE ;

Ferrari, M ;

Haan, J ;

Lindhout, D ;

vanOmmen, GJB ;

Hofker, MH ;

Ferrari, MD ;

Frants, RR .

CELL, 1996, 87 (03) :543-552

[6] Variable clinical expression of mutations in the P/Q-type calcium channel gene in familial hemiplegic migraine [J].

Terwindt, GM ;

Ophoff, RA ;

Haan, J ;

Vergouwe, MN ;

van Eijk, R ;

Frants, RR ;

Ferrari, MD .

NEUROLOGY, 1998, 50 (04) :1105-1111

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