A False-Negative Case of Primary Central Nervous System Lymphoma on 11C-Methionine PET and Intense 18F-FDG Uptake

被引：8
作者：
Garcia-Garzon, J. R. [1 ]
Villasboas-Rosciolesi, Diego [1 ]
Baquero, Miguel [1 ]
Bassa, Pere [1 ]
Soler, Marina [1 ]
Riera, Eduard [1 ]
机构：
[1] CETIR ERESA, PET Unit, C-J Anselm Clave 100, Barcelona 08950, Spain
来源：
CLINICAL NUCLEAR MEDICINE | 2016年 / 41卷 / 08期
关键词：
gliomas; primary central nervous system lymphoma; F-18-FDG PET; C-11-methionine PET; fusion PET/MRI; POSITRON-EMISSION-TOMOGRAPHY;
D O I：
10.1097/RLU.0000000000001258
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
We report a case of a 44-year-old man with neurological symptoms and MRI findings, which were unable to differentiate between glioma and lymphoma. Metabolic characterization by means of PET imaging with 18 F-FDG and 11C-methionine is proposed to determine the benign or tumor (high- and low-grade) origin of brain lesions. In this case, the MRI lesion corresponded with an inconclusive metabolic pattern of intense 18F-FDG uptake and no significant 11C-methionine uptake. Pathological study revealed a false-negative case of 11C-methionine due to lymphoma. © 2016 Wolters Kluwer Health, Inc.
引用
收藏
页码：664 / 665
页数：2
相关论文
共 11 条
[1]   Neuroimaging in brain tumors [J].
Arbizu, J. ;
Dominguez, P. D. ;
Diez-Valle, R. ;
Vigil, C. ;
Garcia-Eulate, R. ;
Zubieta, J. L. ;
Richter, J. A. .
REVISTA ESPANOLA DE MEDICINA NUCLEAR, 2011, 30 (01) :47-65
[2]   Usefulness of 11C-methionine PET in the evaluation of brain lesions that are hypo- or isometabolic on 18F-FDG PET [J].
Chung, JK ;
Kim, YK ;
Kim, SK ;
Lee, YJ ;
Paek, S ;
Yeo, JS ;
Jeong, JM ;
Lee, DS ;
Jung, HW ;
Lee, MC .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2002, 29 (02) :176-182
[3]   11C-methionine PET for differential diagnosis of low-grade gliomas [J].
Herholz, K ;
Hölzer, T ;
Bauer, B ;
Schröder, R ;
Voges, J ;
Ernestus, RI ;
Mendoza, G ;
Weber-Luxenburger, G ;
Löttgen, J ;
Thiel, A ;
Wienhard, K ;
Heiss, WD .
NEUROLOGY, 1998, 50 (05) :1316-1322
[4]   Metabolic assessment of gliomas using 11C-methionine, [18F] fluorodeoxyglucose, and 11C-choline positron-emission tomography [J].
Kato, T. ;
Shinoda, J. ;
Nakayama, N. ;
Miwa, K. ;
Okumura, A. ;
Yano, H. ;
Yoshimura, S. ;
Maruyama, T. ;
Muragaki, Y. ;
Iwama, T. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2008, 29 (06) :1176-1182
[5]   Comparison of 11C-Methionine PET and 18F-FDG PET in Patients with Primary Central Nervous System Lymphoma [J].
Kawase, Yoshiro ;
Yamamoto, Yuka ;
Kameyama, Reiko ;
Kawai, Nobuyuki ;
Kudomi, Nobuyuki ;
Nishiyama, Yoshihiro .
MOLECULAR IMAGING AND BIOLOGY, 2011, 13 (06) :1284-1289
[6]   Usefulness Of L-[methyl-11C] methionine-positron emission tomography as a biological monitoring tool in the treatment of glioma [J].
Nariai, T ;
Tanaka, Y ;
Wakimoto, H ;
Aoyagi, M ;
Tamaki, M ;
Ishiwata, K ;
Senda, M ;
Ishii, K ;
Hirakawa, K ;
Ohno, K .
JOURNAL OF NEUROSURGERY, 2005, 103 (03) :498-507
[7]   Differentiation of Newly Diagnosed Glioblastoma Multiforme and Intracranial Diffuse Large B-cell Lymphoma Using 11C-Methionine and 18F-FDG PET [J].
Okada, Yumiko ;
Nihashi, Takashi ;
Fujii, Masazumi ;
Kato, Katsuhiko ;
Okochi, Yoshiyuki ;
Ando, Yoshio ;
Yamashita, Masato ;
Maesawa, Satoshi ;
Takebayashi, Shigenori ;
Wakabayashi, Toshihiko ;
Naganawa, Shinji .
CLINICAL NUCLEAR MEDICINE, 2012, 37 (09) :843-849
[8]   FDG-PET in immunocompetent patients with primary central nervous system lymphoma: correlation with MRI and clinical follow-up [J].
Palmedo, H ;
Urbach, H ;
Bender, H ;
Schlegel, U ;
Schmidt-Wolf, IGH ;
Matthies, A ;
Linnebank, M ;
Joe, A ;
Bucerius, J ;
Biersack, HJ ;
Pels, H .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2006, 33 (02) :164-168
[9]   Positron emission tomography in patients with primary CNS lymphomas [J].
Roelcke, U ;
Leenders, KL .
JOURNAL OF NEURO-ONCOLOGY, 1999, 43 (03) :231-236
[10]   11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas [J].
Singhal, Tarun ;
Narayanan, Tanjore K. ;
Jain, Viney ;
Mukherjee, Jogeshwar ;
Mantil, Joseph .
MOLECULAR IMAGING AND BIOLOGY, 2008, 10 (01) :1-18
12