Cerebellar dentate nucleus functional connectivity with cerebral cortex in Alzheimer's disease and memory: a seed-based approach

被引：42

作者：

Olivito, Giusy ^{[1
,2
,3
]}

Serra, Laura ^{[3
]}

Marra, Camillo ^{[4
]}

Di Domenico, Carlotta ^{[3
]}

Caltagirone, Carlo ^{[5
,6
]}

Toniolo, Sofia ^{[3
]}

Cercignani, Mara ^{[3
,7
]}

Leggio, Maria ^{[1
,2
]}

Bozzali, Marco ^{[3
,7
]}

机构：

[1] Sapienza Univ Rome, Dept Psychol, Rome, Italy

[2] Fdn Santa Lucia IRCCS, Ataxia Lab, Rome, Italy

[3] Fdn Santa Lucia IRCCS, Neuroimaging Lab, Rome, Italy

[4] Univ Cattolica Sacro Cuore, Fdn Policlin Agostino Gemelli IRCCS, Rome, Italy

[5] Fdn Santa Lucia IRCCS, Dept Clin & Behav Neurol, Rome, Italy

[6] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy

[7] Brighton & Sussex Med Sch, Clin Imaging Sci Ctr, Brighton, E Sussex, England

来源：

NEUROBIOLOGY OF AGING | 2020年 / 89卷

关键词：

Cerebellum; Alzheimer's disease; Functional connectivity; Dentate nucleus; Resting-state fMRI; Memory; RESTING-STATE NETWORKS; CROSSED CEREBELLOCEREBRAL DIASCHISIS; MEDIAL TEMPORAL-LOBE; COGNITIVE FUNCTIONS; PREFRONTAL CORTEX; NORMATIVE DATA; VERBAL MEMORY; MOTOR CORTEX; BRAIN; DISTINCT;

D O I：

10.1016/j.neurobiolaging.2019.10.026

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by specific patterns of gray and white matter damage and cognitive/behavioral manifestations. The cerebellum has also been implicated in the pathophysiology of AD. Because the cerebellum is known to have strong functional connectivity (FC) with associative cerebral cortex regions, it is possible to hypothesize that it is incorporated into intrinsic FC networks relevant to cognitive manifestation of AD. In the present study, the cerebellar dentate nucleus, the largest cerebellar nucleus and the major output channel to the cerebral cortex, was chosen as the region of interest to test potential cerebellocerebral FC alterations and correlations with patients' memory impairment in a group of patients with AD. Compared to controls, patients with AD showed an increase in FC between the dentate nucleus and regions of the lateral temporal lobe. This study demonstrates that lower memory performances in AD may be related to altered FC within specific cerebellocortical functional modules, thus suggesting the cerebellar contribution to AD pathophysiology and typical memory dysfunctions. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：32 / 40

页数：9

共 82 条

[1] MEMORY CONSOLIDATION AND THE MEDIAL TEMPORAL-LOBE - A SIMPLE NETWORK MODEL [J].