Voltage-Gated Calcium Channel Antagonists for the Central Nervous System

被引：9
作者：
Barrow, James C. [1 ]
Duffy, Joseph L. [1 ]
机构：
[1] Merck Res Labs, Rahway, NJ 07065 USA
来源：
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45 | 2010年 / 45卷
关键词：
PLASMA-MEMBRANE EXPRESSION; CA2+ CHANNEL; THALAMIC NEURONS; NEUROPATHIC PAIN; MICE LACKING; ABSENCE EPILEPSY; EPISODIC ATAXIA; BLOCKERS; DISCOVERY; NOMENCLATURE;
D O I：
10.1016/S0065-7743(10)45001-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：3 / 18
页数：16
相关论文
共 50 条
  • [31] Differential effects of voltage-gated calcium channel blockers on calcium channel alpha-2-delta-1 subunit protein-mediated nociception
    Chang, E.
    Chen, X.
    Kim, M.
    Gong, N.
    Bhatia, S.
    Luo, Z. D.
    EUROPEAN JOURNAL OF PAIN, 2015, 19 (05) : 639 - 648
  • [32] Towards multitargeted ligands as pain therapeutics: Dual ligands of the Cavα2δ-1 subunit of voltage-gated calcium channel and the μ-opioid receptor
    Wegert, Anita
    Monnee, Menno
    de Graaf, Wouter
    van Holst, Frank
    Bolcato, Giovanni
    Diaz, Jose Luis
    Dordal, Albert
    Portillo-Salido, Enrique
    Reinoso, Raquel F.
    Yeste, Sandra
    Torrens, Antoni
    Almansa, Carmen
    CHEMMEDCHEM, 2024, 19 (10)
  • [33] Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated CaV2.2 Calcium Channel Activity in Peripheral Axon Terminals Innervating Skin
    DuBreuil, Daniel M.
    Soto, Eduardo Javier Lopez
    Daste, Simon
    Meir, Remy
    Li, Daniel
    Wainger, Brian
    Fleischmann, Alexander
    Lipscombe, Diane
    JOURNAL OF NEUROSCIENCE, 2021, 41 (36) : 7546 - 7560
  • [34] Deletion of the voltage-gated calcium channel, CaV1.3, causes deficits in motor performance and associative learning
    Lauffer, Marisol
    Wen, Hsiang
    Myers, Bryn
    Plumb, Ashley
    Parker, Krystal
    Williams, Aislinn
    GENES BRAIN AND BEHAVIOR, 2022, 21 (02)
  • [35] Voltage-Gated Calcium Channels and α-Synuclein: Implications in Parkinson's Disease
    Leandrou, Emmanouela
    Emmanouilidou, Evangelia
    Vekrellis, Kostas
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 12
  • [36] Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders
    Andrade, Arturo
    Brennecke, Ashton
    Mallat, Shayna
    Brown, Julian
    Gomez-Rivadeneira, Juan
    Czepiel, Natalie
    Londrigan, Laura
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (14)
  • [37] Pain Disorders and Erythromelalgia Caused by Voltage-Gated Sodium Channel Mutations
    Ron Dabby
    Current Neurology and Neuroscience Reports, 2012, 12 : 76 - 83
  • [38] Pain Disorders and Erythromelalgia Caused by Voltage-Gated Sodium Channel Mutations
    Dabby, Ron
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2012, 12 (01) : 76 - 83
  • [39] Isoform Selective Voltage-Gated Sodium Channel Modulators and the Therapy of Pain
    Jukic, Marko
    Kikelj, Danijel
    Anderluh, Marko
    CURRENT MEDICINAL CHEMISTRY, 2014, 21 (02) : 164 - 186
  • [40] A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia
    Morino, Hiroyuki
    Matsuda, Yukiko
    Muguruma, Keiko
    Miyamoto, Ryosuke
    Ohsawa, Ryosuke
    Ohtake, Toshiyuki
    Otobe, Reiko
    Watanabe, Masahiko
    Maruyama, Hirofumi
    Hashimoto, Kouichi
    Kawakami, Hideshi
    MOLECULAR BRAIN, 2015, 8
12345