Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa

被引：9

作者：

Mosam, A ^{[1
]}

Cassol, E

Page, T

Bodasing, U

Cassol, S

Dawood, H

Friedland, GH

Scadden, DT

Aboobaker, J

Jordaan, JP

Lalloo, UG

Esterhuizen, TM

Coovadia, HM

机构：

[1] Africa Ctr Hlth & Populat Studies, Dept Dermatol, Durban, South Africa

[2] Africa Ctr Hlth & Populat Studies, Dept Mol Virol & Bioinformat, Durban, South Africa

[3] Yale Univ, Sch Med, Ctr HIV AIDS Networking, New Haven, CT USA

[4] Yale Univ, Sch Med, Dept Infect Dis, New Haven, CT USA

[5] Yale Univ, Sch Med, AIDS Programme, New Haven, CT USA

[6] Harvard Univ, Sch Med, MGH Canc Ctr, Dept Haematol Malignancies, Cambridge, MA 02138 USA

[7] Univ KwaZulu, Nelson R Mandela Sch Med, Fac Hlth Sci, Dept Radiotherapy & Oncol, Natal, South Africa

[8] Univ KwaZulu, Nelson R Mandela Sch Med, Fac Hlth Sci, Med Bioeth Unit, Natal, South Africa

[9] Univ KwaZulu, Nelson R Mandela Sch Med, Fac Hlth Sci, Victor Diatz Chair HIV AIDS Res, Natal, South Africa

来源：

AIDS | 2005年 / 19卷 / 04期

关键词：

D O I：

10.1097/01.aids.0000161775.36652.85

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Generic antiretroviral drugs are pivotal in the implementation of WHO's '3 by 5' programme. However, clinical experience with generics in sub-Saharan Africa is insufficiently documented. We report on 50 patients with HIV-associated Kaposi's sarcoma treated with generic fixed-dose highly active antiretroviral therapy. At 52 weeks, 74% achieved an undetectable viral load of < 50 copies/ml, 86% achieved < 400 copies/ml, and a 3.1 log(10) decline from baseline. Side-effects were minimal. The outcomes support the use of generic antiretroviral therapy.

引用

页码：441 / 443

页数：3

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