Synthesis of 5′,9-anhydro-3-(β-D-ribofuranosyl)xanthine, and 3,5′-anhydro-xanthosine as potential anti-hepatitis C virus agents

被引：18
作者：
Chun, BK
Wang, PY
Hassan, A
Du, JF
Tharnish, PM
Stuyver, LJ
Otto, MJ
Schinazi, RF
Watanabe, KA
机构：
[1] Pharmasset Inc, Dept Chem, Tucker, GA 30084 USA
[2] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30033 USA
[3] Vet Affairs Med Ctr, Atlanta, GA 30033 USA
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 16期
基金：
美国国家卫生研究院;
关键词：
5; 9-anhydro-3-(beta-D-ribofuranosyl)xanthine; 3,5 '-anhydro-xanthosine; 9-anhydro-3-(beta-D-ribofurnaosyl)purines; 9-anhydro-purine-isonucleosides; anti-hepatitis C virus agent; HCV;
D O I：
10.1016/j.tetlet.2005.02.120
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5 ',9-Anhydro-3-(beta-(D)-ribofuranosyl)xanthine and 3,5 '-anhydro-xanthosine were prepared as potential anti-hepatitis C virus (HCV) agents from uridine and xanthosine, respectively. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：2825 / 2827
页数：3
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