Immunogenicity and safety of a monovalent vaccine for the 2009 pandemic influenza virus A (H1N1) in children and adolescents

被引：34

作者：

Lu, Chun-Yi ^{[1
]}

Shao, Pei-Lan ^{[1
]}

Chang, Luan-Yin ^{[1
]}

Huang, Yhu-Chering ^{[2
]}

Chiu, Cheng-Hsun ^{[2
]}

Hsieh, Yu-Chia ^{[2
]}

Lin, Tzou-Yien ^{[2
]}

Huang, Li-Min ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Dept Pediat, Natl Taiwan Univ Hosp, Taipei 100, Taiwan

[2] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Pediat, Tao Yuan, Taiwan

来源：

VACCINE | 2010年 / 28卷 / 36期

关键词：

H1N1; Vaccine; Children; REACTOGENICITY;

D O I：

10.1016/j.vaccine.2010.06.059

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The 2009 pandemic influenza A (H1N1) has caused significant morbidity and mortality around the world. Safety and immunogenicity studies of 2009 pandemic influenza A (H1N1) virus in children and adolescents are limited. In this prospective, open-label study, 2 doses of a monovalent, unadjuvanted, inactivated, split-virus 2009 pandemic influenza virus A (H1N1) vaccine (AdimFlu-S) were administered to 183 healthy children and adolescents aged 1-17 years. Adverse reactions were assessed, and hemagglutination inhibition antibody titers were determined. Three weeks after the first dose, 36.2% of children aged 1-2 years, 52.5% of children aged 3-5 years, 56.7% of children aged 6-9 years, and 90.3% of adolescents aged 10-17 years generated protective antibodies. A second vaccination given 3 weeks later induced protective antibodies in 89.4% of all age groups. No severe adverse effects were found 6 weeks after vaccination. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5864 / 5870

页数：7

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