Palladium-Catalyzed Intramolecular Amidation of C(sp2)-H Bonds: Synthesis of 4-Aryl-2-quinolinones

被引：102

作者：

Inamoto, Kiyofumi ^{[1
]}

Saito, Tadataka ^{[1
]}

Hiroya, Kou ^{[1
]}

Doi, Takayuki ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 11期

基金：

日本学术振兴会;

关键词：

C-H FUNCTIONALIZATION; CHANNEL OPENING RELAXANTS; DIRECT ARYLATION; AMINATION REACTION; DERIVATIVES; CONSTRUCTION; 2-QUINOLONES; CYCLIZATION; OXIDATION; ALKALOIDS;

D O I：

10.1021/jo100557s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalytic synthetic approach For the synthesis of nolinone compounds through a Pd-catalyzed C(sp(2))-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the presence of a catalytic amount of PdCl2 and Cu(OAc)(2) under an O-2 atmosphere, providing practical access to a range of variously substituted 4-aryl-2-quinolinones.

引用

页码：3900 / 3903

页数：4

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