Carbapenem resistance in Enterobacteriaceae: here is the storm!

被引：805
作者：
Nordmann, Patrice [1 ]
Dortet, Laurent [1 ]
Poirel, Laurent [1 ]
机构：
[1] Hop Bicetre, Assistance Publ Hop Paris, Fac Med Paris Sud, Serv Bacteriol Virol,INSERM Emerging Resistance A, F-94275 Le Kremlin Bicetre, France
来源：
TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 05期
关键词：
antibiotic; Gram-negative bacteria; carbapenemase; beta-lactamases; SPECTRUM-BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; IMIPENEM RESISTANCE; PSEUDOMONAS-AERUGINOSA; SERRATIA-MARCESCENS; ESCHERICHIA-COLI; CLINICAL ISOLATE; IN-VIVO; GENE; PORIN;
D O I：
10.1016/j.molmed.2012.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The current worldwide emergence of resistance to the powerful antibiotic carbapenem in Enterobacteriaceae constitutes an important growing public health threat. Sporadic outbreaks or endemic situations with enterobacterial isolates not susceptible to carbapenems are now reported not only in hospital settings but also in the community. Acquired class A (KPC), class B (IMP, VIM, NDM), or class D (OXA-48, OXA-181) carbapenemases, are the most important determinants sustaining resistance to carbapenems. The corresponding genes are mostly plasmid-located and associated with various mobile genetic structures (insertion sequences, integrons, transposons), further enhancing their spread. This review summarizes the current knowledge on carbapenem resistance in Enterobacteriaceae, including activity, distribution, clinical impact, and possible novel antibiotic pathways.
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收藏
页码：263 / 272
页数：10
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