Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

被引：272

作者：

Gorter, Thomas M. ^{[1
]}

van Veldhuisen, Dirk J. ^{[1
]}

Bauersachs, Johann ^{[2
]}

Borlaug, Barry A. ^{[3
]}

Celutkiene, Jelena ^{[4
]}

Coats, Andrew J. S. ^{[5
,6
]}

Crespo-Leiro, Marisa G. ^{[7
]}

Guazzi, Marco ^{[8
]}

Harjola, Veli-Pekka ^{[9
]}

Heymans, Stephane ^{[10
]}

Hill, Loreena ^{[11
]}

Lainscak, Mitja ^{[12
]}

Lam, Carolyn S. P. ^{[13
]}

Lund, Lars H. ^{[14
]}

Lyon, Alexander R. ^{[15
,16
]}

Mebazaa, Alexandre ^{[17
]}

Mueller, Christian ^{[18
]}

Paulus, Walter J. ^{[19
]}

Pieske, Burkert ^{[20
,21
,22
]}

Piepoli, Massimo F. ^{[23
]}

Ruschitzka, Frank ^{[24
]}

Rutten, Frans H. ^{[25
]}

Seferovic, Petar M. ^{[26
]}

Solomon, Scott D. ^{[27
]}

Shah, Sanjiv J. ^{[28
]}

Triposkiadis, Filippos ^{[29
]}

Wachter, Rolf ^{[30
,31
]}

Tschoepe, Carsten ^{[20
,21
,22
]}

de Boer, Rudolf A. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[2] Med Sch Hannover, Dept Cardiol & Angiol, Hannover, Germany

[3] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA

[4] Vilnius Univ, Clin Cardiac & Vasc Dis, Fac Med, Vilnius, Lithuania

[5] Monash Univ, Clayton Campus, Melbourne, Vic 3800, Australia

[6] Univ Warwick, Kirby Corner Rd, Coventry CV4 8UW, W Midlands, England

[7] Univ Coruna UDC, Inst Invest Biomed Coruna INIBIC, Adv Heart Failure & Heart Transplant Unit, Serv Cardiol CIBERCV,CHUAC, La Coruna, Spain

[8] Univ Milan, IRCCS, Policlin San Donato, Heart Failure Unit, Milan, Italy

[9] Univ Helsinki, Helsinki Univ Hosp, Dept Emergency Med & Serv, Emergency Med, Helsinki, Finland

[10] Maastricht Univ, Med Ctr, CARIM, Dept Cardiol, Maastricht, Netherlands

[11] Queens Univ, Belfast, Antrim, North Ireland

[12] Gen Hosp Murska Sobota, Dept Internal Med, Murska Sobota, Slovenia

[13] Natl Heart Ctr Singapore, Singapore Duke NUS Grad Med Sch, Dept Cardiol, Singapore, Singapore

[14] Karolinska Univ Hosp, Karolinska Inst & Heart & Vasc Theme, Dept Med, Stockholm, Sweden

[15] Imperial Coll London, Natl Heart & Lung Inst, London, England

[16] Royal Brompton Hosp, London, England

[17] Univ Paris Diderot, St Louis Lariboisiere Univ Hosp, AP HP, Dept Anesthesiol & Crit Care, Paris, France

[18] Univ Basel Hosp, Cardiovasc Res Inst Basel, Dept Cardiol, Basel, Switzerland

[19] Vrije Univ Amsterdam Med Ctr, Dept Cardiol, Amsterdam, Netherlands

[20] Charite, Dept Internal Med & Cardiol, Berlin, Germany

[21] DZHK German Ctr Cardiovasc Res, German Heart Ctr Berlin, Dept Internal Med Cardiol, Berlin, Germany

[22] Berlin Inst Hlth, Berlin, Germany

[23] Guglielmo da Saliceto Hosp, Cardiac Dept, Heart Failure Unit, Piacenza, Italy

[24] Univ Hosp Zurich, Clin Cardiol, Zurich, Switzerland

[25] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[26] Clin Ctr Serbia, Med Sch, Cardiol Dept, Belgrade, Serbia

[27] Brigham & Womens Hosp, Div Cardiovasc, 75 Francis St, Boston, MA 02115 USA

[28] Northwestern Univ, Feinberg Sch Med, Div Cardiol, Chicago, IL 60611 USA

[29] Larissa Univ Hosp, Dept Cardiol, Larisa, Greece

[30] Univ Hosp Leipzig, Clin & Policlin Cardiol, Leipzig, Germany

[31] German Cardiovasc Res Ctr, Partner Site Gottingen, Gottingen, Germany

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2018年 / 20卷 / 01期

关键词：

Heart failure; Right ventricular function; Pulmonary hypertension; Biomarkers; Heart failure with preserved ejection fraction; RIGHT-VENTRICULAR FUNCTION; PULMONARY ARTERIAL-HYPERTENSION; CHRONIC KIDNEY-DISEASE; EXERCISE CAPACITY; ATRIAL-FIBRILLATION; MAGNETIC-RESONANCE; CARDIAC STRUCTURE; PHOSPHODIESTERASE-5; INHIBITION; DIASTOLIC DYSFUNCTION; SYSTOLIC FUNCTION;

D O I：

10.1002/ejhf.1029

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.

引用

页码：16 / 37

页数：22

共 175 条

[41] Pulmonary Hypertension Is Related to Peripheral Endothelial Dysfunction in Heart Failure With Preserved Ejection Fraction [J].

Farrero, Marta ;

Blanco, Isabel ;

Batlle, Montserrat ;

Santiago, Evelyn ;

Cardona, Montserrat ;

Vidal, Barbara ;

Angeles Castel, M. ;

Sitges, Marta ;

Albert Barbera, Joan ;

Perez-Villa, Felix .

CIRCULATION-HEART FAILURE, 2014, 7 (05) :791-798

[42] Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure Rationale and Design of the Randomized Trial to REDUCE Elevated Left Atrial Pressure in Heart Failure (REDUCE LAP-HF I) [J].

Feldman, Ted ;

Komtebedde, Jan ;

Burkhoff, Daniel ;

Massaro, Joseph ;

Maurer, Mathew S. ;

Leon, Martin B. ;

Kaye, David ;

Silvestry, Frank E. ;

Cleland, John G. F. ;

Kitzman, Dalane ;

Kubo, Spencer H. ;

Van Veldhuisen, Dirk J. ;

Kleber, Franz ;

Trochu, Jean-Noel ;

Auricchio, Angelo ;

Gustafsson, Finn ;

Hasenfuss, Gerd ;

Ponikowski, Piotr ;

Filippatos, Gerasimos ;

Mauri, Laura ;

Shah, Sanjiv J. .

CIRCULATION-HEART FAILURE, 2016, 9 (07)

[43] Ranolazine for the treatment of pulmonary hypertension associated with heart failure with preserved ejection fraction: A pilot study [J].

Finch, Kimberly T. ;

Stratton, Eric A. ;

Farber, Harrison W. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2016, 35 (11) :1370-1373

[44] Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparisonwith cardiac magnetic resonance [J].

Focardi, Marta ;

Cameli, Matteo ;

Carbone, Salvatore Francesco ;

Massoni, Alberto ;

De Vito, Raffaella ;

Lisi, Matteo ;

Mondillo, Sergio .

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2015, 16 (01) :47-52

[45] Prognostic incremental role of right ventricular function in acute decompensation of advanced chronic heart failure [J].

Frea, Simone ;

Pidello, Stefano ;

Bovolo, Virginia ;

Iacovino, Cristina ;

Franco, Erica ;

Pinneri, Francesco ;

Galluzzo, Alessandro ;

Volpe, Alessandra ;

Visconti, Massimiliano ;

Peirone, Andrea ;

Morello, Mara ;

Bergerone, Serena ;

Gaita, Fiorenzo .

EUROPEAN JOURNAL OF HEART FAILURE, 2016, 18 (05) :564-572

[46] MR and CT Imaging for the Evaluation of Pulmonary Hypertension [J].

Freed, Benjamin H. ;

Collins, Jeremy D. ;

Francois, Christopher J. ;

Barker, Alex J. ;

Cuttica, Michael J. ;

Chesler, Naomi C. ;

Markl, Michael ;

Shah, Sanjiv J. .

JACC-CARDIOVASCULAR IMAGING, 2016, 9 (06) :715-732

[47] Prognostic Utility and Clinical Significance of Cardiac Mechanics in Heart Failure With Preserved Ejection Fraction Importance of Left Atrial Strain [J].

Freed, Benjamin H. ;

Daruwalla, Vistasp ;

Cheng, Jeanette Y. ;

Aguilar, Frank G. ;

Beussink, Lauren ;

Choi, Andrew ;

Klein, David A. ;

Dixon, Debra ;

Baldridge, Abigail ;

Rasmussen-Torvik, Laura J. ;

Maganti, Kameswari ;

Shah, Sanjiv J. .

CIRCULATION-CARDIOVASCULAR IMAGING, 2016, 9 (03)

[48] Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertension [J].

Freed, Benjamin H. ;

Gomberg-Maitland, Mardi ;

Chandra, Sonal ;

Mor-Avi, Victor ;

Rich, Stuart ;

Archer, Stephen L. ;

Jamison, E. Bruce, Jr. ;

Lang, Roberto M. ;

Patel, Amit R. .

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2012, 14

[49] 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension [J].

Galie, Nazzareno ;

Humbert, Marc ;

Vachiery, Jean-Luc ;

Gibbs, Simon ;

Lang, Irene ;

Torbicki, Adam ;

Simonneau, Gerald ;

Peacock, Andrew ;

Noordegraaf, Anton Vonk ;

Beghetti, Maurice ;

Ghofrani, Ardeschir ;

Sanchez, Miguel Angel Gomez ;

Hansmann, Georg ;

Klepetko, Walter ;

Lancellotti, Patrizio ;

Matucci, Marco ;

McDonagh, Theresa ;

Pierard, Luc A. ;

Trindade, Pedro T. ;

Zompatori, Maurizio ;

Hoeper, Marius .

EUROPEAN RESPIRATORY JOURNAL, 2015, 46 (04) :903-975

[50] Pulmonary Hypertension in Heart Failure Epidemiology, Right Ventricular Function, and Survival [J].

Gerges, Mario ;

Gerges, Christian ;

Pistritto, Anna-Maria ;

Lang, Marie B. ;

Trip, Pia ;

Jakowitsch, Johannes ;

Binder, Thomas ;

Lang, Irene M. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 192 (10) :1234-1246

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